Fig. 4
From: Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11
Effect of the miR-181b/SLC7A11 axis on MIA-induced osteoarticular cartilage injury in rats. (A) HE staining results. (B) Safranin O-fast green staining results. (C) IHC detection of aggrecan and MMP-13 protein expression levels. (D-E) Quantification of the IHC results. (F-I) Western blot analysis of collagen II, aggrecan and MMP-13 protein expression levels and the quantitative results. **P < 0.01, *P < 0.05, the model group was significantly different from the sham group. A-C: MIA group: treated with MIA, antagomiR-181b group: treated with MIA + antagomiR-181b, antagomiR-181b + sh-SLC7A11 group: treated with MIA + sh-SLC7A11. ##P < 0.01, #P < 0.05, the two groups of the line were compared, and the difference was statistically significant