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Table 1 Demographic and clinical characteristics of training sets and validation sets

From: Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram

predictors

Training cohort(n = 258)

P

Validation cohort(n = 110)

P

 

Musculoskeletal pain(n = 118)

Non-musculoskeletal pain (n = 140 )

 

Musculoskeletal pain(n = 46)

Non-musculoskeletal pain (n = 64)

 

Gender,n(%)

  

0.256

  

0.701

Male

20(17.8%)

33 (23.6%)

 

8 (17.4%)

13 (20.3%)

 

Female

98(82.2%)

107(76.4%)

 

38 (82.6%)

51 (79.7%)

 

Age,years,n(%)

  

0.000

  

0.000

< 60

60–70

70–80

5 (4.3%)

22 (18.6%)

68 (57.6%)

7 (5.0%)

16 (11.4%)

20 (14.3%)

 

3 (6.5%)

19 (41.3%)

13 (28.3%)

3 (4.7%)

5(7.8%)

14 (21.9%)

 

>80

23 (19.5%)

97 (69.3%)

 

11 (23.9%)

42 (65.6%)

 

BMI, n(%)

  

0.000

  

0.001

< 24

77 (65.3%)

57 (40.7%)

 

30 (65.2%)

22 (34.4%)

 

≥ 24

41 (32.7%)

83 (59.3%)

 

16 (34.8%)

42 (65.6%)

 

NSAIDs

  

0.003

  

0.000

Yes

15(12.7%)

115(82.1%)

 

7(15.2%)

51(79.7%)

 

No

103(87.3%)

25(17.9%)

 

39(84.8%)

13(20.3%)

 

Fluidinfusion

  

0.000

  

0.027

Yes

68 (57.6%)

92 (65.7%)

 

33(55.4%)

34(52.9%)

 

No

50 (42.4%)

50 (42.4%)

 

13(44.6%)

30(47.1%)

 

Fracture

  

0.668

  

0.977

Yes

55(46.6%)

69(49.3%)

 

20(43.5%)

28(43.8%)

 

No

63(53.4%)

71(50.7%)

 

26(56.5%)

36(56.3%)

 

25(OH)D

  

0.000

  

0.000

< 30

90(76.3%)

38(27.1%)

 

32(69.6%)

18(28.1%)

 

≥ 30

28(23.7%)

102(72.9%)

 

14(30.4%)

46(71.9%)

 

PTH

  

0.050

  

0.562

< 70

93(73.8%)

123(87.9%)

 

36(78.3%)

47(73.4%)

 

≥ 70

25(21.2%)

17(12.1%)

 

10 (21.7%)

17(26.6%)

 

OC

  

0.196

  

0.033

15–46

93(78.8%)

119(85.0%)

 

29(63.0%)

52(81.2%)

 

≤ 15 or ≥ 46

25(21.2%)

21(15.0%)

 

17(37.0%)

12(18.8%)

 

T-index

  

0.777

  

0.899

≤-2.5

72(60.0%)

83(59.3%)

 

25(54.3%)

34(53.1%)

 

0-2.5–3.0

46(39.0%)

57(40.7%)

 

21(46.7%)

30(46.9%)

 

prior Vitamin D intake

  

0.000

  

0.000

supplement

96(81.4%)

30(21.4%)

 

37(80.4%)

21(32.8%)

 

no supplement

22(18.6%)

111(78.6%)

 

9(19.6%)

43(67.2%)