Table 1 Included articles’ characteristics:
Author (year) | Study design | Group | Sample size | Surgery approach | Administration and dosage | Age (mean ± SD) | Gender M/F |
|---|---|---|---|---|---|---|---|
Ju Tang, et al. (2018) | NRSI | Control | 296 | Open internal combined with external arthrolysis | Treated as in the case group except for treatment of TA | 65.30 ± 4.11 | 133/163 |
Intervention | 291 | 15 mg/kg, 15 min before loose tourniquet + 500 mg infusion by drainage tube after suture | 65.15 ± 3.52 | 125/166 | |||
Nitin Goyal, et al. (2020) | NRSI | Control | 25 | Open anterior and posterior joint releases | Treated as in the case group except for treatment of TA | 45 ± 15 | 18/25 |
Intervention | 25 | 1 g within 30 min of incision + a single topical dose of TA (1 g in 20 mL saline solution) was infused through a deep hemovac drain after fascial closure. | 45 ± 13 | 20/25 | |||
Eugene T. Ek, et al. (2022) | NRSI | Control | 43 | Arthroscopic osteocapsular release | Treated as in the case group except for treatment of TA | 49.9 ± 13.3 | 33/10 |
Intervention | 40 | 1 g, completion of the arthroscopic procedure while the wounds were being closed, inflated tourniquet | 45.9 ± 15.1 | 29/11 | |||
Haomin Cui, et al. (2021) | RCT | Control | 48 | Open elbow arthrolysis | 100 mL saline, 10 min before skin incision | 40 ± 10 | 35/13 |
Intervention | 48 | 1 g TXA in 100 mL saline, 10 min before skin incision | 40 ± 12 | 28/20 |