Table 2 | Functional roles of 10 hub genes with degree ≥ 10
No | Gene symbol | Full name | Function |
|---|---|---|---|
1 | EP300 | E1A Binding Protein P300 | Functions as histone acetyltransferase and regulates transcription via chromatin remodeling |
2 | DNMT1 | Gene—DNA Methyltransferase 1 | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand |
3 | TRIM28 | Tripartite Motif Containing 28 | Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)to the promoter regions of KRAB target genes |
4 | SETD1A | SET Domain Containing 1A, Histone Lysine Methyltransferase | Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place |
5 | DDB1 | Damage Specific DNA Binding Protein 1 | Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes |
6 | MTA2 | Metastasis Associated 1 Family Member 2 | May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins |
7 | EP400 | E1A Binding Protein P400 | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A |
8 | PARP1 | Gene—Poly(ADP-Ribose) Polymerase 1 | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair |
9 | BAZ1B | Bromodomain Adjacent To Zinc Finger Domain 1B Chromobox 1 | Atypical tyrosine-protein kinase that plays a central role in chro- matin remodeling and acts as a transcription regulator |
10 | CBX1 | Chro- mobox 1 | Recognizes and binds histone H3 tails methylated at ’Lys-9’, lead- ing to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. |