Table 3 PRP preparation and administration

Guney et al.2016

6.4

Not Reported

1

-

4mL per time;

PRP injected 6–24 h post-microfracture at time of Hemovac drain removal;

Rehabilitation program

Not Reported

Not Reported

Guney et al.2015

6.4

Not Reported

1

-

Dose unknown;

PRP injected 6–24 h post-microfracture at time of Hemovac drain removal;

Rehabilitation program

Not Reported

Not Reported

Görmeli et al.2015

5.2

Not Reported

1

-

Dose unknown;

PRP injected 24–36 h post-microfracture at time of Hemovac drain removal;

Rehabilitation program

Not Reported

Not Reported

Paget et al.2021

Not Reported Leukocyte-Poor

2

6 weeks

2mL

Education leaflet

Nonactivated

1st centrifugation: 5 min;

Sampson S et al. 2016

4.2

Leukocyte-Poor

1

-

1–2 cc;

Bone marrow concentrate was injected intra-articular 8 weeks before PRP;

Rehabilitation program or home exercise program

Nonactivated

1st centrifugation: 2800 rpm for 10 min;

2nd centrifugation: 3400 rpm for 6 min;

Fukawa et al. 2017

5.1

Leukocyte-Poor

3

2 weeks

2mL per time;

Ultrasound guided;

Not reported

Calcium chloride

1st centrifugation: 800 g for 5 min;

2nd centrifugation: 1500 g for 8 min;

Li et al. 2021

Not Reported

3

During surgery;

4, 12 weeks after surgery;

5mL per time;

Not reported

Not reported

1st centrifugation: 2000 r / min for 10 min;

2nd centrifugation: 2000 r / min for 10 min;

Repetto et al. 2017

2–3

Leukocyte-Poor

4

1 week

3mL per time;

Not reported

Not reported

1st centrifugation: 3550 rpm for 12 min;

2nd centrifugation: 1100 rpm for 10 min;

3rd centrifugation: 2600 rpm for 20 min;

Akpancar et al. 2019

Not Reported

3

3 weeks

4mL per time;

2 mL for intra-articular and 2 mL for tibial edge and talar dome adjacent to the joint surface;

Not reported

Nonactivated

1st centrifugation: 3200 rpm for 15 min;

Mei-Dan et al. 2012

Not Reported

3

2 weeks

2mL per time;

Avoid unnecessary walking for 24 h.

Avoid sports activity or heavy physical work for 2 to 3 days after injection.

Avoid nonsteroidal anti-inflammatory medications for 2 weeks after the last injection

Calcium chloride

1st centrifugation: 640 g for 8 min;