Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study

Table 3 Association between SUA levels and BMD in different models

	Model 1^a N = 1249 β (95%CI) P-value	Model 2^b N = 1249 β (95%CI) P-value	Model 3^c N = 1249 β (95%CI) P-value	Model 4^d N = 1249 β (95%CI) P-value
Serum uric acid per 100 μmol/L increase	0.0440 (0.0350, 0.0530) < 0.000001	0.0288 (0.0199, 0.0377) < 0.000001	0.0286 (0.0193, 0.0378) < 0.000001	0.0235(0.0139, 0.0330) 0.000002
Serum uric acid quartile
Q1(< 231 μmol/L)	Reference	Reference	Reference	Reference
Q2(231–278 μmol/L)	0.0327 (0.0113, 0.0542) 0.002863	0.0163 (-0.0038, 0.0365) 0.112425	0.0163 (-0.0039, 0.0364) 0.114381	0.0135 (-0.0066, 0.0337) 0.187813
Q3(278-341 μmol/L)	0.0677 (0.0462, 0.0891) < 0.000001	0.0451 (0.0248, 0.0653) 0.000014	0.0445 (0.0241, 0.0649) 0.000020	0.0391 (0.0185, 0.0596) 0.000199
Q4(> 341 μmol/L)	0.0924 (0.0710, 0.1139) < 0.000001	0.0558 (0.0348, 0.0769) < 0.000001	0.0547 (0.0331, 0.0763) < 0.000001	0.0428 (0.0207, 0.0650) 0.000153
P-value for trend	< 0.000001	< 0.000001	< 0.000001	0.000034

Abbreviations: SUA serum uric acid, BMD bone mineral density, CI confidence interval, Q1 first quartile, Q2 second quartile, Q3 third quartile, Q4 fourth quartile, BMI body mass index, 25(OH)D 25-hydroxy vitamin D, BUN blood urea nitrogen, ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine
^aNo adjustment
^bAdjusted for age, gender, BMI, 25(OH)D levels
^cAdjusted for age, gender, BMI, 25(OH)D levels, BUN
^d Adjusted for age, gender, BMI, 25(OH)D levels, primary diagnosis, BUN, ALT, AST, Cr

ISSN: 1471-2474