Table 1 Inclusion criteria

Design:

 - Randomised and clinical controlled trials

 - Cross-sectional, cohort, and case–control studies

 - Case-series

Participants:

 - N ≥ 10

 - Mean/median age ≥ 18

 - Underwent lower limb-salvage surgery for any type of bone cancer

 - Unilateral, primary surgery

Intervention:

 - Any type of pre- or postoperative exercise intervention, without any further restrictions, as long as the movements were performed actively by the patient

 - Less than six months between surgery and the intervention’s start

Outcome measures:

 - Focussing on physical activity, physical activity behaviour and/or functioning, or mental health

Control group (not mandatory):

 - Healthy controls, usual care, or another exercise intervention