Table 1 Baseline characteristics stratified by the optimal cutoff point of ApoA1
From: Association of apolipoprotein A1 with osteoporosis: a cross-sectional study
Total population (n = 7743) | Lower ApoA1 (n = 3359) | Higher ApoA1 (n = 4384) | P value | |
|---|---|---|---|---|
Age, years | 49.20 ± 19.68 | 47.51 ± 19.71 | 50.49 ± 19.56 | < 0.001 |
Sex, male, n (%) | 3910 (50.50%) | 2138 (63.60%) | 1772 (40.40%) | < 0.001 |
Race, n (%) | < 0.001 | |||
Non-Hispanic White | 3514 (45.40%) | 1565 (46.60%) | 1949 (44.50%) | |
Non-Hispanic Black | 1886 (24.40%) | 623 (18.50%) | 1263 (28.80%) | |
Mexican-American | 2100 (27.10%) | 1066 (31.70%) | 1034 (23.60%) | |
Others | 243 (3.10%) | 105 (3.10%) | 138 (3.10%) | |
Smoking status, n (%) | < 0.001 | |||
Every day | 3592 (46.40%) | 1419 (42.30%) | 2173 (49.60%) | |
Some days | 2044 (26.40%) | 929 (27.70%) | 1115 (25.40%) | |
Not at all | 2106 (27.20%) | 1010 (30.10%) | 1096 (25.00%) | |
Comorbidities, n (%) | ||||
Hypertension | 2872 (37.10%) | 1174 (35.00%) | 1698 (38.70%) | < 0.001 |
Diabetes | 1203 (15.50%) | 511 (15.20%) | 692 (15.80%) | 0.213 |
Hypercholesterolemia | 1240 (33.30%) | 479 (30.90%) | 761 (35.00%) | 0.010 |
Gout | 245 (3.20%) | 123 (3.70%) | 122 (2.80%) | 0.047 |
Medication, n (%) | ||||
Hypotensive drugs | 1229 (15.90%) | 520 (15.50%) | 709 (16.20%) | 0.702 |
Hypoglycemic drugs | 443 (5.70%) | 207 (6.20%) | 236 (5.40%) | 0.288 |
Cholesterol-lowering drugs | 227 (8.20%) | 107 (8.90%) | 120 (7.60%) | 0.225 |
BMI, kg/m2 | 26.77 ± 5.55 | 23.26 ± 3.90 | 24.51 ± 3.48 | 0.027 |
SBP, mmHg | 126.12 ± 19.53 | 125.03 ± 18.57 | 126.95 ± 20.20 | < 0.001 |
DBP, mmHg | 74.08 ± 10.62 | 74.20 ± 10.54 | 73.99 ± 10.68 | 0.393 |
TG, mmol/L | 1.29 (0.89, 1.93) | 1.41 (0.97, 2.18) | 1.19 (0.84, 1.74) | < 0.001 |
TC, mmol/L | 5.37 ± 1.16 | 5.14 ± 1.11 | 5.56 ± 1.16 | < 0.001 |
LDL-C, mmol/L | 3.35 ± 1.00 | 3.31 ± 0.95 | 3.39 ± 1.04 | 0.030 |
HDL-C, mmol/L | 1.33 ± 0.40 | 1.07 ± 0.24 | 1.54 ± 0.38 | < 0.001 |
ApoB, g/L | 1.07 ± 0.27 | 1.07 ± 0.26 | 1.06 ± 0.28 | 0.065 |
BUN, mmol/L | 5.33 ± 2.26 | 5.40 ± 2.30 | 5.26 ± 2.22 | 0.008 |
CR, umol/L | 96.49 ± 34.01 | 98.99 ± 36.10 | 94.55 ± 32.18 | < 0.001 |
Albumin, g/L | 42.34 ± 3.89 | 42.85 ± 3.98 | 41.94 ± 3.76 | < 0.001 |
Uric acid, umol/L | 318.37 ± 90.24 | 332.97 ± 89.18 | 307.06 ± 89.45 | < 0.001 |
FPG, mmol/L | 5.24 (4.89, 5.69) | 5.27 (4.94, 5.72) | 5.22 (4.85, 5.67) | < 0.001 |
HbA1c, % | 5.52 ± 1.10 | 5.54 ± 1.12 | 5.50 ± 1.09 | 0.152 |
CRP, mg/dL | 0.21 (0.21, 0.44) | 0.21 (0.21, 0.44) | 0.21 (0.21, 0.33) | 0.002 |
ALP, U/L | 84.66 ± 34.72 | 86.57 ± 29.72 | 83.18 ± 38.08 | < 0.001 |
Total calcium, mmol/L | 2.34 ± 0.11 | 2.33 ± 0.11 | 2.34 ± 0.11 | 0.005 |
25(OH) D, nmol/L | 55.50 ± 20.15 | 56.10 ± 19.69 | 55.04 ± 20.48 | 0.023 |
Osteoporosis, n (%) | 188 (2.40%) | 40 (1.20%) | 148 (3.40%) | < 0.001 |