Table 2 Comparison of synovial fluid parameters before and after treatment

HMGB1 (pg/ml)

1349 ± 767.8

839.4 ± 629.4

-509.4 ± 112.168(-738.80, -279.99)

0.01

RAGE(pg/ml)

225.3 ± 44.83

211.8 ± 34.94

-13.58 ± 10.95(-35.97, 8.81)

0.196

TLR4(pg/ml)

1860 ± 855.8

1393 ± 582.2

-467.53 ± 187.48(-850.97, -84.08)

0.0296

IL-1β(pg/ml)

599.1 ± 191.1

455 ± 96.74

-144.13 ± 35.55(-216.85, -71.42)

0.0009

IL-18(pg/ml)

369.7 ± 137.2

303.6 ± 104.3

-66.09 ± 31.37(-130.25, -1.92)

0.04

PGE2(pg/ml)

259.3 ± 80.71

170.1 ± 76.37

-89.16 ± 23.12(-136.45, -41.87)

 < 0.0001

iNOS(ng/ml)

0.2612 ± 0.0746

0.2132 ± 0.07905

-0.0479 ± 0.0187(-0.0863, -0.0096)

0.0189