Table 6 Cartilage damage change – any MOAKS worsening (baseline to 24 months)

Worsening—total MOAKS cartilage score (only full-grade worsening)

Knee

None vs. any

0

106

46.9

69

63.3

37

31.6

0.0000

 ≥ 1

120

53.1

43

36.7

80

68.4

Number of regions

1

60

26.5

26

23.9

34

29.1

2

35

15.5

9

8.3

26

22.2

3

17

7.5

3

2.8

14

12.0

4

6

2.7

2

1.8

4

3.4

5

2

0.9

0

0.0

2

1.7

MFTJ

None vs. any

0

172

76.1

96

88.1

76

65.0

0.0000

 ≥ 1

54

23.9

13

11.9

41

35.0

Number of regions

1

40

17.7

11

10.1

29

24.8

2

12

5.3

1

0.9

11

9.4

3

2

0.9

1

0.9

1

0.9

LFTJ

None vs. any

0

176

77.9

99

90.8

77

65.8

0.0000

 ≥ 1

50

22.1

10

9.2

40

34.2

Number of regions

1

35

15.5

8

7.3

27

23.1

2

11

4.9

2

1.8

9

7.7

3

3

1.3

0

0.0

3

2.6

4

1

0.4

0

0.0

1

0.9

PFJ

None vs. any

0

168

74.3

83

76.1

85

72.6

0.5176

 ≥ 1

58

25.7

26

23.9

32

27.4

Number of regions

1

43

19.0

20

18.3

23

19.7

2

13

5.8

5

4.6

8

6.8

3

2

0.9

1

0.9

1

0.9

Worsening—total score including within-grade worsening

Knee

None vs. any

0

85

37.6

61

56.0

24

20.5

0.0000

 ≥ 1

141

73.9

48

44.0

93

79.5

Number of regions

1

59

26.1

30

27.5

29

24.8

2

43

19.0

12

11.0

31

26.5

3

29

12.8

4

3.7

25

21.4

4

7

3.1

2

1.8

5

4.3

5

3

1.3

0

0.0

3

2.6

MFTJ

None vs. any

0

154

68.1

93

85.3

61

52.1

0.0000

 ≥ 1

72

31.9

16

14.7

56

47.9

Number of regions

1

50

22.1

13

11.9

37

31.6

2

16

7.1

2

1.8

14

12.0

3

6

2.7

1

0.9

5

4.3

LFTJ

None vs. any

0

168

74.3

97

89.0

71

60.7

0.0000

 ≥ 1

58

25.7

12

11.0

46

39.3

Number of regions

1

38

16.8

10

9.2

28

23.9

2

16

7.1

2

1.8

14

12.0

3

3

1.3

0

0.0

3

2.6

4

1

0.4

0

0.0

1

0.9

PFJ

None vs. any

0

154

68.1

77

70.6

77

65.8

0.3948

 ≥ 1

72

31.9

32

29.4

40

34.2

Number of regions

1

54

23.9

25

22.9

29

24.8

2

16

7.1

6

5.5

10

8.5

3

2

0.9

1

0.9

1

0.9