Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C. A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco, Francisco J.; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P. J. G.; Weinans, Harrie H.; Wirth, Wolfgang

doi:10.1186/s12891-022-05926-1

Table 3 Intra- and Inter-reader Reliability APPROACH MOAKS Assessment (Change)

From: Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

N = 20		Intra-observer				Inter-observer
N = 20		Weighted Kappa	Std. Error	95% CI		Weighted Kappa	Std. Error	95% CI
Maximum increase in MOAKS cartilage score	MFTJ	0.67	0.17	0.34	1.01	0.37	0.24	-0.10	0.84
	LFTJ	1.00	0.00	1.00	1.00	0.68	0.23	0.22	1.14
	PFJ	0.58	0.20	0.19	0.97	0.38	0.22	-0.05	0.81
	Knee	0.73	0.16	0.43	1.04	0.56	0.19	0.19	0.92
Maximum increase in cartilage area score	MFTJ	0.64	0.33	0.01	1.28	0.36	0.29	-0.20	0.93
	LFTJ	1.00	0.00	1.00	1.00	0.64	0.33	0.01	1.28
	PFJ	0.63	0.20	0.24	1.01	0.41	0.21	-0.01	0.83
	Knee	0.76	0.16	0.45	1.07	0.56	0.21	0.14	0.97
Maximum increase in cartilage full thickness score	MFTJ	0.76	0.16	0.45	1.07	0.47	0.22	0.04	0.90
	LFTJ	1.00	0.00	1.00	1.00	0.72	0.21	0.31	1.12
	PFJ	0.48	0.25	-0.02	0.98	0.32	0.30	-0.27	0.90
	Knee	0.74	0.15	0.46	1.03	0.65	0.16	0.33	0.97
Maximum increase in BML size score	MFTJ	0.76	0.17	0.43	1.10	0.54	0.15	0.23	0.84
	LFTJ	0.88	0.13	0.62	1.13	0.77	0.18	0.42	1.12
	PFJ	0.48	0.25	-0.02	0.98	0.23	0.26	-0.29	0.75
	Knee	0.87	0.10	0.68	1.06	0.79	0.10	0.60	0.99
Change in number of regions with BML score > 0	MFTJ	0.63	0.23	0.18	1.08	0.52	0.22	0.08	0.96
	LFTJ	0.65	0.27	0.12	1.18	0.53	0.17	0.20	0.87
	PFJ	0.79	0.21	0.38	1.19	0.47	0.32	-0.15	1.09
	Knee	0.55	0.22	0.13	0.98	0.57	0.17	0.24	0.89
Maximum increase in osteophyte score	MFTJ^a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
	LFTJ	0.64	0.33	0.01	1.28	1.00	0.00	1.00	1.00
	PFJ	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
	Knee	0.46	0.31	-0.14	1.06	0.61	0.25	0.11	1.10
Max increase in meniscus morphology score (range 0…8)	MFTJ	0.84	0.11	0.62	1.06	0.84	0.17	0.52	1.17
Max increase in meniscus morphology score (range 0…8)	LFTJ	0.63	0.29	0.07	1.19	0.24	0.20	-0.14	0.63
Max increase in meniscus extrusion (range 0…3)	MFTJ	1.00	0.00	1.00	1.00	0.00	0.00	0.00	0.00
Max increase in meniscus extrusion (range 0…3)	LFTJ	0.00	0.00	0.00	0.00	0.79	0.23	0.33	1.25
Max increase in hoffa synovitis	Knee	0.64	0.33	0.00	1.28	0.31	0.30	-0.27	0.90
Max increase in effusion synovitis	Knee	0.85	0.11	0.64	1.06	0.44	0.16	0.14	0.75

MFTJ medial tibio-femoral joint, LFTJ lateral tibio-femoral joint, PFJ Patellofemoral joint, Std standard
^aIn none of the knees an increase in osteophyte size in the medial tibio-femoral joint (MFTJ) was observed (both readers)

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