Table 1 Overview of tranexamic acid administration (indication, contraindication, adjustments in renal insufficiency)

Indication for the administration of tranexamic acid

All hip fractures

Contraindications to the administration of tranexamic acid

Known intolerance

Severe renal insufficiency (risk of accumulation; see below)

Congenital or acquired thrombophilia

Acute arterial and venous thrombosis

Patient history of arterial/venous thrombosis or ischaemic stroke

History of stent implantation under dual platelet inhibition

Known epilepsy

Pregnancy and lactation

Hyperfibrinolysis as a result of disseminated intravascular coagulopathy

Bleeds in the urinary tract

Patients taking oral contraceptives (increased thrombogenic risk)

Adjustments in case of renal insufficiency

Serum creatinine 120 to 249 μmol/l: 10 mg/kg body weight (no further administration for the next 12 h)

Serum creatinine 250 to 500 μmol/l: 10 mg/kg body weight (no further administration for the next 24 h)