A2A adenosine receptor agonist reduced MMP8 expression in healthy M2-like macrophages but not in macrophages from ankylosing spondylitis patients

Table 5 Matrix of Spearman’s correlation coefficient between the mRNA expressions of BMP2, MMP8, and MMP9 genes and clinical manifestations of patients

	*ESR*	*BASMI*	*BASFI*	*BASDAI*	*BASG*	*PGDA*	*ASQol*
*BMP2*	− 0.133	0.049	0.132	− 0.066	− 0.025	− 0.051	0.037
*MMP8*	0.220	0.148	0.639*	0.498	− 0.042	0.395	0.458
*MMP9*	0.082	− 0.114	− 0.025	− 0.006	0.014	0.183	− 0.150

BMP: Bone morphogenetic protein, MMP: Matrix metalloproteinase, ESR: Erythrocyte sedimentation rate, BASMI: Bath Ankylosing Spondylitis Metrology Index, BASFI: Bath Ankylosing Spondylitis Functional Index, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, BASG: Bath Ankylosing Spondylitis Global Score, PGDA: Patient global disease activity, ASQoL: Ankylosing Spondylitis Quality of Life, SD: Standard deviation. * p < 0.05; ** p < 0.01; *** p < 0.001

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