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Table 4 Individual background factors and risk of first incident fracture in the multivariable-adjusted model

From: Early menopause and weight loss are significant factors associated with risk of future fracture in middle-aged women

 

(n = 12,018a)

HRb

95% CIc

p-value

Age at baseline

(years)

1.07

1.06–1.07

< 0.001

Body mass index (BMI)

(kg/m2)

0.95

0.94–0.97

< 0.001

Previous fracture

(yes)

1.64

1.43–1.88

< 0.001

Current smoking

(yes)

1.12

1.04–1.20

0.003

Living alone

(yes)

1.03

0.96–1.10

0.44

Family history of fractures

(yes)

1.12

1.05–1.20

0.001

Weight at baseline

(kg)

1.01

1.01–1.02

0.001

Weight change since 20 years of age

 It has been the same

 

Reference

  

 Gradually increased

 

0.99

0.90–1.10

0.897

 Gradually decreased

 

1.39

1.17–1.65

< 0.001

 My weight has varied

 

1.07

0.96–1.19

0.22

Alcohol

(g/day)

   

 Quartile 1 (0–0.80)

 

Reference

  

 Quartile 2 (0.81–5.35)

 

0.96

0.88–1.04

0.285

 Quartile 3 (5.36–11.42)

 

0.88

0.81–0.96

0.002

 Quartile 4 (> 11.43)

 

0.96

0.88–1.05

0.346

Number of born children

 no children

 

Reference

  

 1–2 children

 

0.99

0.86–1.14

0.902

  ≥ 3 children

 

1.02

0.88–1.19

0.782

Total duration of lactation

(months)

   

 no lactation

 

Reference

  

 1–6

 

0.96

0.85–1.09

0.554

 7–18

 

0.97

0.86–1.09

0.586

  ≥ 19

 

0.94

0.80–1.10

0.434

Age at menopause

(years)

   

  < 40

 

1.06

0.91–1.24

0.439

 40–44

 

1.14

1.03–1.27

0.009

 45–54

 

Reference

  

  > 55

 

0.97

0.88–1.07

0.501

  1. Individual background factors in relation to first incident fracture in a multivariable Cox regression model
  2. aThe multivariate model includes 12,018 women. This is due to missing-data for some variables, which is the greatest for age at menopause (n = 5855)
  3. bHazard Ratios
  4. cConfidence Interval