Fig. 2

Construction and functional analysis of co-expression networks. A Co-expression network diagram of circRNAs and mRNAs with significant differences. The square represents the circRNAs, the circle represents the mRNAs and the colour change from blue to red represents the change in |Log₂FC| from low to high. B Bubble diagram of GO biological process and KEGG signalling pathway of mRNAs in the co-expression network. The horizontal axis represents the number of genes, and the vertical axis represents the names of GO and KEGG signalling pathways. The size and colour of the node represent − log₁₀(p value)