Fig. 2

Radiography and histopathology of the hip. Radiography and histopathology of the hip in the Sham and MIA groups (0.25-mg, 0.5-mg, 1.0-mg, 2.0-mg, and 4.0-mg) 12 weeks after MIA administration. a–f Anteroposterior radiographs of the rat hip. g–l Hematoxylin and eosin-stained tissues. m–r Safranin O-stained tissues. As the MIA dose increased, OA changes progressed both radiologically and histologically. At concentrations of 0.5 mg MIA and higher, end-stage joint destruction was observed at 12 weeks. Abbreviations: MIA, monoiodoacetate; OA, osteoarthritis