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Table 1 Patient characteristics

From: Risk factors of fracture following curettage for bone giant cell tumors of the extremities

Variable (n = 284) No. of patients Filler
Sex   PMMA bone cement alone (n = 124) PMMA bone cement and allograft bone grafting (n = 81) Allograft or hydroxyapatite grafting (n = 79)
Male 131 (46.1%) 58 (46.4%) 43 (53.1%) 30 (38.5%)
Female 153 (53.9%) 67 (53.6%) 38 (46.9%) 48 (61.5%)
Age (years)
 Median 30 30.7 28.4 29.5
 Interquartile range 23.2–40.3 26.0–42.2 21.9–38.3 21.5–40.8
Site
 Distal radius 21 (7.4%) 12 (9.7%) 1 (1.2%) 8 (10.1%)
 Proximal femur 13 (4.6%) 1 (0.8%) 5 (6.2%) 7 (8.9%)
 Distal femur 94 (33.1%) 56 (45.1%) 28 (34.6%) 10 (12.7%)
 Proximal tibia 95 (33.5%) 35 (28.2%) 37 (45.7%) 23 (29.1%)
 Distal tibia 16 (5.6%) 5 (4.0%) 4 (4.9%) 7 (8.9%)
 Proximal humerus 12 (4.2%) 8 (6.5%) 1 (1.2%) 3 (3.8%)
 Othersa 33 (11.6%) 8 (6.5%) 5 (6.2%) 20 (25.3%)
Campanacci classification
 Stage I 7 (2.5%) 1 (0.8%) 2 (2.5%) 4 (5.1%)
 Stage II 220 (77.5%) 101 (80.8%) 60 (74.1%) 59 (75.6%)
 Stage III 57 (20.1%) 23 (18.4%) 19 (23.5%) 15 (19.2%)
Pathological fracture at presentation
 No 267 (94.0%) 118 (94.4%) 80 (98.8%) 69 (88.5%)
 Yes 17 (6.0%) 7 (5.6%) 1 (1.2%) 9 (11.5%)
Denosumab administration
 No 254 (89.4%) 107 (85.6%) 76 (93.8%) 71 (91.0%)
 Yes 30 (10.6%) 18 (14.4%) 5 (6.2%) 7 (9.0%)
Previous surgery
 No 251 (88.4%) 109 (87.2%) 72 (88.9%) 70 (89.7%)
 Yes 33 (11.6%) 16 (12.8%) 9 (11.1%) 8 (10.3%)
Local adjuvant therapy
 No 37 (13.0%) 19 (15.2%) 2 (2.5%) 16 (20.5%)
 Yes 247 (87.0%) 106 (84.8%) 79 (97.5%) 62 (79.5%)
Fracture
 No 274 (96.5%) 116 (92.8%) 80 (98.8%) 78 (100%)
 Yes 10 (3.5%) 9 (7.2%) 1 (1.2%) 0
Local recurrence
 None 217 (76.4%) 102 (81.6%) 65 (80.3%) 51 (65.4%)
  ≥ 1 67 (23.6%) 23 (18.4%) 16 (19.8%) 27 (34.6%)
Follow-up (months)
 Median 86.5 83.2 94.5 88.3
 Interquartile range 50.3–118.8 45.8–101.9 63.6–133.0 45.3–144
  1. PMMA Polymethylmethacrylate
  2. aOther sites include the distal ulna (7), talus (6), distal humerus (6), calcaneus (3), cuboid (2), hand phalanges (2), foot phalanges (2), proximal ulna (2), proximal radius (1), proximal fibula (1), and metatarsal (1)