Association of bone-related biomarkers with femoral neck bone strength

Table 2 Comparison of serum BTMs levels in each group

Parameters	Normal ^a (n = 27)	Osteopenia ^b (n = 27)	Osteoporosis ^c (n = 27)	Severe osteoporosis ^d (n = 27)	P-value
CTX (ng/ml)	0.29 ± 0.14	0.52 ± 0.16^*	0.65 ± 0.20^*	0.78 ± 0.23^*#	< 0.0001
PINP (ng/ml)	44.00 ± 12.55	48.30 ± 15.95	62.11 ± 21.04^*	65.04 ± 23.73^*	< 0.0001
OC (ng/ml)	8.33 ± 4.18	10.41 ± 4.67	17.70 ± 8.26^*#	18.75 ± 10.45^*#	< 0.0001

Data are presented as the mean ± SD for CTX, PINP and OC
^a T-score ≥ -1.0
^b T-score < -1.0 and > -2.5
^c At least one of the following criteria fulfilled: (a) T-score ≤ -2.5; (b) femoral neck fragile fracture)
^d Fragility fracture with a T-score ≤ -2.5
^*P < 0.05, compared with normal group
^#P < 0.05, compared with osteopenia group
^▲ P < 0.05, compared with OP group
CTX C-terminal telopeptide of type I collagen, PINP type I procollagen N-terminal propeptide, OC osteocalcin

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