Table 3 Clinical course and follow-up
Patient | Age/Sex | Location | Surgery before | Transformation of Desmoid-type Formation(DTF) | Treatment process | Pathological finding | Follow-up | |
|---|---|---|---|---|---|---|---|---|
Tumor recurrence frequency | Current condition | |||||||
1 | 22/F | sciatic nerve | Yes | Yes | Tumor resection (Once) | β-Catenin ( +) | 0 | No progression |
2 | 2/M | sciatic nerve | Yes | Yes | Surgical biopsy of sciatic nerve | β-Catenin ( +) | 0 | Progression of motor deficit, limb undergrowth and calf muscles atrophy |
3 | 6/M | sciatic nerve | Yes | Yes | Tumor resection (Once); chemotherapy (Two cycles); HIFU (Six rounds); | β-Catenin ( +) CTNNB1 p. S45F mutation | Once (At the site of NMC) | Continuous tumor progression lead to above-knee amputation |
4 | 10/F | brachial plexus | Yes | Yes | Tumor and involved brachial plexus resection, nerve transplantation | β-Catenin ( +) | 0 | No progression after nerve transplantation |
5 | 2/M | sciatic nerve | Yes | Yes | Tumor resection (Three times); radiotherapy (A course) | β-Catenin ( +) | Twice (At the site of NMC) | No progression after last treatment |
6 | 4/M | sciatic nerve | No | No | None | — | 0 | No progression |
7 | 3/F | sciatic nerve | No | No | None | — | 0 | No progression |