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Table 1 Group demographics and study characteristics

From: Hyaluronic acid as an adjunct to microfracture in the treatment of osteochondral lesions of the talus: a systematic review of randomized controlled trials

Author, Year

No. of Ankles

Intervention

Comparator(s)

Average Age ± SD

Average Follow-Up

LOE

MQOE

Gormeli et al., 2015 [41]

40

MF/HA group

Arthroscopic MF and subsequent HA injection

MF/PRP group

Arthroscopic MF and subsequent PRP injection

MF/saline group

Arthroscopic MF and subsequent saline injection

MF/HA group

39.7 ± 8.7 years

MF/PRP group

38.6 ± 9.1 years

MF/saline group

40.3 ± 9.4 years

15.3 months

(range, 11–25)

1

81

Doral et al., 2012 [43]

57

MF/HA group

Arthroscopic MF and subsequent weekly HA injection for three weeks

MF group

Arthroscopic MF alone

MF/HA group

Not reported

MF group

Not reported

Combined

40.5 ± 13.0 years

≥24 months

2

83

Shang et al., 2016 [42]

35

MF/HA group

Arthroscopic MF and subsequent weekly HA injection for three weeks

MF group

Arthroscopic MF alone

MF/HA group

34.7 ± 8.7 years

MF group

36.6 ± 10.7 years

MF/HA group

10.4 months

(SD, 1.3)

MF group

10.7 months

(SD, 1.1)

1

77

  1. Abbreviations: SD Standard deviation, LOE Level of evidence, MQOE Methodological quality of evidence, MF Microfracture surgery, HA Hyaluronic acid, PRP Plate-rich plasma