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Table 4 Certainty of evidence for decrease of pain during distraction phase

From: Efficacy and safety of botulinum toxin type A in distraction osteogenesis of the lower extremities: a meta-analysis of randomized controlled trials

  1. BoNT Botulinum neurotoxin, CI Confidence interval, SMD Standardized mean difference
  2. aMost studies included scored low risk of bias during assessment
  3. bI2 score was below 50%
  4. cNo indirectness was detected in this outcome
  5. dThe upper and lower limit of 95% CI ranged from favoring placebo to favoring BoNT
  6. eThis was calculated by pooling the placebo group of the 2 articles included in the primary outcome presenting sufficient data (Hamdy et al., 2009, 2016), comparing the pain score before surgery and during distraction phase
  7. fThis was calculated by pooling the BoNT group of the 2 articles included in the primary outcome presenting sufficient data (Hamdy et al., 2009, 2016), comparing the pain score before surgery and during distraction phase
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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