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Table 1 Characteristics of patients with RA

From: Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis

 

ILD

 

UIP

 

NSIP

 

AD

Emphysema

 

CLD(+)

 

CLD(−)

 

P

 

P

 

P

 

P

 

P

 

P

 

Number, n

115

 

46

 

69

 

112

 

37

 

264

 

189

Mean age, years (SD)

67.2 (8.3)

0.0009

67.1 (9.1)

0.0137

67.3 (7.8)

0.0061

65.6 (9.8)

0.0553

66.3 (8.1)

0.1247

66.4 (9.0)

0.0013

62.8 (11.1)

Male, n (%)

27 (23.5)

*0.3076

16 (34.8)

*0.0267

11 (15.9)

*0.7155

15 (13.4)

*0.2667

22 (59.5)

*1.06 × 10−6

64 (24.2)

*0.1668

35 (18.5)

Age at onset, years (SD)

54.1 (12.9)

0.0018

54.0 (14.3)

0.0336

54.2 (12.0)

0.0067

50.5 (14.6)

0.2257

56.5 (11.2)

0.0012

52.9 (13.6)

0.0014

49.2 (13.2)

Steinbrocker stages III and IV, n (%)

53 (46.1)

*0.0773

25 (54.3)

*0.8687

28 (40.6)

*0.0248

65 (58.6)

*0.8092

13 (35.1)

*0.0194

131 (49.8)

*0.1812

107 (56.6)

Smoker or former smoker, n (%)

42 (38.5)

*0.1186

18 (40.9)

*0.1471

24 (36.9)

*0.2730

41 (41.0)

*0.0469

28 (84.8)

*1.98 × 10−9

111 (45.9)

*0.0005

51 (29.0)

KL-6, U/ml (SD)

726.6 (639.4)

1.11 × 10−15

749.9 (652.6)

1.77 × 10− 9

710.5 (635.1)

3.10 × 10−12

383.2 (330.0)

0.0012

585.5 (466.0)

1.92 × 10−6

585.3 (546.4)

2.60 × 10−13

293.6 (294.4)

SP-D, ng/ml (SD)

122.3 (144.9)

1.95 × 10−9

128.6 (92.6)

2.43 × 10− 7

117.9 (173.8)

2.27 × 10−6

67.2 (70.9)

0.1588

93.2 (69.5)

0.0003

99.2 (117.4)

4.58 × 10−7

51.1 (40.9)

  1. AD Airway disease, CLD Chronic lung disease, CLD(+), with CLD, CLD(−), without CLD, KL-6 Krebs von den lungen-6, NSIP Nonspecific interstitial pneumonia, RA Rheumatoid arthritis, SP-D Surfactant protein-D, UIP Usual interstitial pneumonia
  2. ILD group includes UIP and NSIP groups. CLD(+) group includes UIP, NSIP, AD, and emphysema groups
  3. Data are presented as the mean value or number of each group. Standard deviations or percentages are shown in parentheses. Statistical differences were tested in comparison with the CLD(−) population by Fisher’s exact test using 2 × 2 contingency tables or the Mann–Whitney U test. *Fisher’s exact test