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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

Fig. 5

M-HDAC4 repress cartilage hypertrophy and enhance anabolism in rat OA model. a, b Levels of mRNA for Runx-2 and MMP-13 were lower in rats that were treated with Ad-m-HDAC4 or Ad-HDAC4 compared to the rats that underwent ACLT and treated with Ad-GFP. In addition, these 2 genes were expressed at a lower level in the Ad-m-HDAC4 treated rats than in the Ad-HDAC4 treated rats. In contrast, the mRNA levels of Col 2a1 (c) and ACAN (d) were elevated in rats that were treated with Ad-m-HDAC4 or Ad-HDAC4 compared to the rats that underwent ACLT and treated with Ad-GFP, and the mRNA expression of Col 2a1 and ACAN were greater in the Ad-m-HDAC4 treated rats than in the Ad-HDAC4 treated rats.* indicates P < 0.05

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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