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Table 2 Characteristics of patients and management according to the treatment outcome

From: Effectiveness of early switching from intravenous to oral antibiotic therapy in Staphylococcus aureus prosthetic bone and joint or orthopedic metalware-associated infections

 

Failure n(%)

p-value

Sex

 

0.97

 Male

8/92 (8.7)

 

 Female

4/48 (8.3)

 

Type of prosthetic material

 

0.001

 Total hip replacement

2/38 (5.3)

 

 Total knee replacement

5/13 (38.5)

 

 Total ankle replacement

0/2 (0)

 

 All prosthesis

7/53 (13.2)

 

 Intramedullary nailing

2/16 (12.5)

 

 Plate/screw/pin

3/71 (4.2)

 

Type of surgery

 

0.33

 Intra-articular washa

6 (11.3)

 

 One-stage revision

2 (15.4)

 

 Two-stage revision

3 (14.3)

 

 Material removal

1 (2.5)

 

 Mobile inserts change

0 (0)

 

Type of infection

 

0.01

 Type I

0/5(0)

 

 Type II

2/58 (3.5)

 

 Type III

2/51 (4)

 

 Type IV

6/28 (21.5)

 

 Infection by inoculation

9/115 (7.8)

 

S. aureus susceptibility

 

0.01

Methicillin susceptible

6/113 (5.3)

 

Methicillin resistant

6/27 (22.2)

 

Intravenous antibiotic therapy

 

0.15

 Empiric therapy following guidelines

6/104 (5.7)

 

 Empiric therapy not following guidelines

6/26 (16.6)

 

Duration of intravenous antibiotic therapy

 

0.47

  ≤ 5 days

9/119 (7.5)

 

  > 5 days

3/21 (14.2)

 

Oral antibiotic therapy

 

0.42

 Rifampicin + Ofloxacin

6/88 (6.8)

 

 Rifampicin + Cotrimoxazole

2/21 (4.8)

 

 Rifampicin + another antibiotic

2/8 (25.0)

 

 Combination without rifampicin

3/22 (13.6)

 

Chronic comorbidities

 

0.17

 Diabetes mellitus

2/21 (9.5)

 

 Obesity

4/24 (16.7)

 

 Chronic renal failure

1/12 (8.3)

 

 Cancer, history of radiotherapy, immunosuppressive therapy

0/25 (0)

 
  1. aopen debridement without exchange of modular components
  2. References [4, 5]