Skip to main content

Table 2 Proposed significance of biomarkers

From: A systematic review of the role of inflammatory biomarkers in acute, subacute and chronic non-specific low back pain

BiomarkerRationale Supporting Examination of Association with NSLBP
hsCRP/CRP hsCRP has been found to be associated with patients with osteoarthritis [29]
It has also been found that individuals with acute sciatic pain also have elevated hsCRP levels [29]
IL-6 Previous research has shown that proinflammatory cytokines such as IL-6 may be involved in pain processes [31]
IL-6 has been shown to modulate nociception and possibly contribute to intensifying pain experiences [31]
Increased IL-6 levels have also been associated with greater pain severity in individuals with rheumatoid arthritis, fibromyalgia and postoperative procedures [31]
TNF-α Has been shown to have a role in pathophysiology of discogenic back pain and sciatica [25]
Has been identified to use in possible treatment strategies of lumbar radicular pain [25]
Previous studies have shown elevated TNF-α levels in individuals with NSLBP [26]
IL-1β Proinflammatory and pro-nociceptive cytokine [24]
Has been shown to be involved in neurodegeneration, chronic inflammation and chronic pain [24]
Has been shown to have increased levels in complex regional pain syndrome and chronic tension-type headache [30]
  1. NSLBP Non-specific low back pain, hsCRP High sensitivity c-reactive protein, CRP: c-reactive protein, IL-6 Interleukin 6, TNF-α Tumor necrosis factor alpha, IL-1β Interleukin 1 beta