Table 1 Patient demographics, knee function, pain intensity and inflammatory mediator expression in different K-L grade groups
From: Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis
| Â | K-L grade | Average | |||
|---|---|---|---|---|---|
1 | 2 | 3 | 4 | ||
Male/Female | 5/15 | 15/33 | 1/11 | 0/3 | 21/62 |
Age (years) | 56.6 ± 9.2 | 63.3 ± 8.8 | 72.1 ± 11.2 | 74.0 ± 6.6 | 63.4 ± 10.4 |
ROM (°) | 121.5 (117.7–125.2) | 114.4 (110.1–118.6) | 92.1 (75.1–109.1) | 91.7 (44.6–138.7) | 112.0 (108.0–116.1) |
WOMAC | 15.2 (10.6–19.7) | 23.8 (19.7–27.9) | 41.8 (28.2–55.3) | 58.3 (37.2–79.5) | 25.5 (21.7–29.3) |
NRS | 2.0 (1.4–2.5) | 2.9 (2.5–3.3) | 4.6 (3.3–5.9) | 6.3 (−0.8–13.5) | 3.04 (2.63–3.44) |
VAS (cm) | 2.5 (1.6–3.5) | 3.5 (2.9–4.0) | 4.7 (3.4–6.0) | 7.0 (2.7–11.3) | 3.55 (3.09–4.03) |
WOMAC Pain | 3.0 (2.0–4.0) | 4.8 (4.0–5.6) | 7.8 (4.7–10.8) | 11.7 (5.9–17.4) | 5.05 (4.29–5.81) |
Neuropathic Pain | 2.7 (0.9–4.5) | 2.4 (1.5–3.4) | 4.3 (1.5–7.0) | 6.0 (−0.6–12.6) | 2.89 (2.12–3.67) |
IL-1β (pg/mL) | 40.7 (37.4–44.0) | 38.8 (36.8–40.9) | 32.4 (28.7–36.2) | 29.0 (5.40–52.7) | 38.0 (36.3–39.6) |
IL-6 (pg/mL) | 30.3 (28.3–32.3) | 29.7 (28.6–30.8) | 26.7 (24.6–28.7) | 25.9 (14.8–37.1) | 29.3 (28.4–30.1) |
TNF-α (pg/mL) | 666.3 (591.2–741.5) | 669.7 (616.6–722.8) | 575.3 (473.2–677.4) | 524.1 (64.4–1112.6) | 650.0 (611.1–688.8) |
M-CSF (pg/mL) | 302.7 (273.7–331.8) | 282.9 (266.2–299.6) | 321.1 (293.8–348.4) | 339.1 (321.6–356.6) | 295.2 (282.7–307.8) |
MMP-3 (ng/mL) | 337.3 (351.4–403.2) | 372.2 (355.2–389.2) | 368.3 (328.0–408.6) | 420.7 (321.8–519.6) | 374.6 (362.0–387.2) |
MMP-13 (ng/mL) | 208.0 (192.8–233.2) | 213.0 (200.6–225.4) | 228.6 (219.7–246.5) | 250.7 (146.9–354.5) | 215.4 (206.9–224.0) |
ADAMTS5 (U/mL) | 45.3 (41.7–49.0) | 42.6 (39.9–45.2) | 44.6 (37.1–50.2) | 41.5 (27.6–55.3) | 43.5 (41.6–45.4) |
BK (ng/mL) | 5.67 (5.05–6.28) | 5.68 (5.33–6.03) | 6.15 (5.37–6.93) | 6.28 (5.41–7.16) | 5.77 (5.50–6.03) |
CGRP (pg/mL) | 94.7 (84.8–104.5) | 91.4 (84.2–98.6) | 95.1 (78.6–111.6) | 109.9 (25.6–194.2) | 93.4 (88.1–98.7) |
SP (pg/mL) | 109.7 (98.4–121.0) | 105.6 (98.9–112.2) | 103.3 (85.2–121.4) | 96.2 (6.03–186.4) | 105.9 (100.6–111.2) |
NPY (ng/mL) | 170.5 (155.2–185.8) | 177.7 (168.9–186.4) | 180.6 (161.9–199.2) | 180.1 (111.3–249.0) | 176.5 (169.9–183.1) |