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Table 1 Patient demographics, knee function, pain intensity and inflammatory mediator expression in different K-L grade groups

From: Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis

 K-L gradeAverage
1234
Male/Female5/1515/331/110/321/62
Age (years)56.6 ± 9.263.3 ± 8.872.1 ± 11.274.0 ± 6.663.4 ± 10.4
ROM (°)121.5 (117.7–125.2)114.4 (110.1–118.6)92.1 (75.1–109.1)91.7 (44.6–138.7)112.0 (108.0–116.1)
WOMAC15.2 (10.6–19.7)23.8 (19.7–27.9)41.8 (28.2–55.3)58.3 (37.2–79.5)25.5 (21.7–29.3)
NRS2.0 (1.4–2.5)2.9 (2.5–3.3)4.6 (3.3–5.9)6.3 (−0.8–13.5)3.04 (2.63–3.44)
VAS (cm)2.5 (1.6–3.5)3.5 (2.9–4.0)4.7 (3.4–6.0)7.0 (2.7–11.3)3.55 (3.09–4.03)
WOMAC Pain3.0 (2.0–4.0)4.8 (4.0–5.6)7.8 (4.7–10.8)11.7 (5.9–17.4)5.05 (4.29–5.81)
Neuropathic Pain2.7 (0.9–4.5)2.4 (1.5–3.4)4.3 (1.5–7.0)6.0 (−0.6–12.6)2.89 (2.12–3.67)
IL-1β (pg/mL)40.7 (37.4–44.0)38.8 (36.8–40.9)32.4 (28.7–36.2)29.0 (5.40–52.7)38.0 (36.3–39.6)
IL-6 (pg/mL)30.3 (28.3–32.3)29.7 (28.6–30.8)26.7 (24.6–28.7)25.9 (14.8–37.1)29.3 (28.4–30.1)
TNF-α (pg/mL)666.3 (591.2–741.5)669.7 (616.6–722.8)575.3 (473.2–677.4)524.1 (64.4–1112.6)650.0 (611.1–688.8)
M-CSF (pg/mL)302.7 (273.7–331.8)282.9 (266.2–299.6)321.1 (293.8–348.4)339.1 (321.6–356.6)295.2 (282.7–307.8)
MMP-3 (ng/mL)337.3 (351.4–403.2)372.2 (355.2–389.2)368.3 (328.0–408.6)420.7 (321.8–519.6)374.6 (362.0–387.2)
MMP-13 (ng/mL)208.0 (192.8–233.2)213.0 (200.6–225.4)228.6 (219.7–246.5)250.7 (146.9–354.5)215.4 (206.9–224.0)
ADAMTS5 (U/mL)45.3 (41.7–49.0)42.6 (39.9–45.2)44.6 (37.1–50.2)41.5 (27.6–55.3)43.5 (41.6–45.4)
BK (ng/mL)5.67 (5.05–6.28)5.68 (5.33–6.03)6.15 (5.37–6.93)6.28 (5.41–7.16)5.77 (5.50–6.03)
CGRP (pg/mL)94.7 (84.8–104.5)91.4 (84.2–98.6)95.1 (78.6–111.6)109.9 (25.6–194.2)93.4 (88.1–98.7)
SP (pg/mL)109.7 (98.4–121.0)105.6 (98.9–112.2)103.3 (85.2–121.4)96.2 (6.03–186.4)105.9 (100.6–111.2)
NPY (ng/mL)170.5 (155.2–185.8)177.7 (168.9–186.4)180.6 (161.9–199.2)180.1 (111.3–249.0)176.5 (169.9–183.1)
  1. ROM range of motion; NRS numeric rating scale; VAS visual analog scale; WOMAC Western Ontario and McMaster Universities Osteoarthritis Index; IL-1β interleukin 1β; IL-6 interleukin 6; TNF-α tumor necrosis factor α; M-CSF macrophage colony-stimulating factor; MMP-3 matrix metalloproteinase 3; MMP-13 matrix metalloproteinase 13; ADAMTS5 metalloproteinase with thrombospondin motifs 5; CGRP calcitonin gene-related peptide; NPY neuropeptide Y; SP substance P; BK bradykinin