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Table 4 Univariate and multivariate cox regression models of tuberculosis in SpA

From: Risk of tuberculosis in patients with spondyloarthritis: data from a centralized electronic database in Hong Kong

 

Univariate regression

Multivariate logistic regression

Characteristic

Hazard Ratio (95% CI)

P value

Hazard Ratio (95% CI)

P value

Age (years)

0.93 (0.91–0.95)

< 0.001

0.94 (0.91–0.96)

< 0.001

Male sex

2.29 (1.02–5.15)

0.05

1.88 (0.79–4.50)

0.16

Smoking

1.74 (0.95–3.19)

0.07

1.19 (0.60–2.35)

0.62

Alcohol use

2.29 (1.06–4.94)

0.04

2.44 (1.03–5.80)

0.04

History of psoriasis

0.51 (0.21–1.20)

0.12

  

History of IBD

1.43 (0.20–10.37)

0.73

  

DM

0.72 (0.26–2.03)

0.54

  

Past history of TB

6.88 (3.28–14.41)

< 0.001

5.92 (2.52–13.94)

< 0.001

CKD

0.89 (0.32–2.51)

0.83

  

CLD

4.48 (2.07–9.72)

< 0.001

3.81 (1.60–9.06)

0.002

Malignancy

2.07 (0.74–5.80)

0.17

  

CHD

0.88 (0.31–2.47)

0.81

  

Other immunosuppressive states

0.95 (0.13–6.89)

0.96

  

History of CVA

1.46 (0.52–4.09)

0.48

  

Glucocorticoid therapy > 6 months

2.21 (0.93–5.25)

0.03

2.60 (1.01–6.70)

0.05

Sulfasalazine

0.63 (0.34–1.16)

0.14

  

Methotrexate

0.57 (0.27–1.19)

0.13

  

Lefluonomide

0.05 (0.00–13.72)

0.29

  

Infliximab

5.08 (2.49–10.34)

< 0.001

3.94 (1.82–8.53)

< 0.001

Etanercept

0.57 (0.14–2.36)

0.44

  

Adalimumab

1.83 (0.72–4.67)

0.21

  

Certolizumab

0.05 (0.00–32,169)

0.66

  

Golimumab

0.05 (0.00–13.94)

0.29

  

Secukinumab

0.05 (0.00–282.43)

0.49

  

Ustekinumab

0.05 (0.00–657,547)

0.72

  
  1. SpA Spondyloarthritis; CI Confidence interval; IBD Inflammatory bowel disease; DM Diabetes mellitus; TB Tuberculosis; CKD Chronic kidney disease; CLD Chronic lung disease; CHD Chronic heart disease; CVA Cerebrovascular accident