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Table 2 Concentration of biomarkers, expressed as median values (25th and 75th percentiles), in acute and chronic samples

From: Higher aggrecan 1-F21 epitope concentration in synovial fluid early after anterior cruciate ligament injury is associated with worse knee cartilage quality assessed by gadolinium enhanced magnetic resonance imaging 20 years later

Biomarkers

Acute samples

Chronic samples

1P-values

 

Concentration

N

Concentration

N

 

sGAG, μg/ml

181.8 (116.8, 323,8)

16

58.1 (42.8, 75,1)

21

< 0.001

1-F21 agcan, μg/ml

679.0 (413.4, 873.6)

16

117.0 (85.6, 168.3)

14

< 0.001

ARGS agcan, nM

11.5 (6.8, 21.1)

18

1.5 (1.1, 2.1)

22

< 0.001

COMP, μg/ml

180.0 (146.5, 214.5)

13

57.0 (52.3, 73.0)

12

< 0.001

MMP-3, nM

37.5 (21.4, 56.8)

18

5.2 (1.5, 8.5)

17

< 0.001

TIMP-1, nM

52.5 (43.1, 67.8)

18

7.3 (5.7, 9.3)

17

< 0.001

sGAG/COMP

1.08 (0.7, 1.6)

11

0.9 (0.8, 1.1)

12

0.295

1-F21 agcan/COMP

4.9 (1.7, 5.7)

11

1.5 (1.2, 2.5)

9

0.038

ARGS agcan/COMP

0.07 (0.04, 0.10)

12

0.02 (0.02, 0.03)

12

0.002

MMP-3/TIMP-1

0.7 (0.4, 1.1)

18

0.6 (0.3, 1.0)

17

0.642

  1. 1) Statistical analyses using Mann Whitney.
  2. sGAG Sulfated glycosaminoglycans, 1-F21 agcan 1-F21 epitope of aggrecan, ARGS agcan ARGS neoepitope of aggrecan, COMP Cartilage oligomeric matrix protein, MMP-3 Matrix metalloproteinase 3, TIMP-1 Tissue inhibitor of metalloproteinase 1.