Skip to main content

Table 2 Concentration of biomarkers, expressed as median values (25th and 75th percentiles), in acute and chronic samples

From: Higher aggrecan 1-F21 epitope concentration in synovial fluid early after anterior cruciate ligament injury is associated with worse knee cartilage quality assessed by gadolinium enhanced magnetic resonance imaging 20 years later

Biomarkers Acute samples Chronic samples 1P-values
  Concentration N Concentration N  
sGAG, μg/ml 181.8 (116.8, 323,8) 16 58.1 (42.8, 75,1) 21 < 0.001
1-F21 agcan, μg/ml 679.0 (413.4, 873.6) 16 117.0 (85.6, 168.3) 14 < 0.001
ARGS agcan, nM 11.5 (6.8, 21.1) 18 1.5 (1.1, 2.1) 22 < 0.001
COMP, μg/ml 180.0 (146.5, 214.5) 13 57.0 (52.3, 73.0) 12 < 0.001
MMP-3, nM 37.5 (21.4, 56.8) 18 5.2 (1.5, 8.5) 17 < 0.001
TIMP-1, nM 52.5 (43.1, 67.8) 18 7.3 (5.7, 9.3) 17 < 0.001
sGAG/COMP 1.08 (0.7, 1.6) 11 0.9 (0.8, 1.1) 12 0.295
1-F21 agcan/COMP 4.9 (1.7, 5.7) 11 1.5 (1.2, 2.5) 9 0.038
ARGS agcan/COMP 0.07 (0.04, 0.10) 12 0.02 (0.02, 0.03) 12 0.002
MMP-3/TIMP-1 0.7 (0.4, 1.1) 18 0.6 (0.3, 1.0) 17 0.642
  1. 1) Statistical analyses using Mann Whitney.
  2. sGAG Sulfated glycosaminoglycans, 1-F21 agcan 1-F21 epitope of aggrecan, ARGS agcan ARGS neoepitope of aggrecan, COMP Cartilage oligomeric matrix protein, MMP-3 Matrix metalloproteinase 3, TIMP-1 Tissue inhibitor of metalloproteinase 1.