Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept

Table 2 Bone density and cortical shell volume differences

Treatment Group	Bone Density, Mean ± SD, mgHA/cm³	Mature – New Bone Volume, Mean ± SD, mm³
Naive	646.0 ± 17.8^a	19.7 ± 1.7^b,c
Disease control	628.5 ± 26.1	6.9 ± 7.2
ETN 10 mg/kg	605.9 ± 35.7	6.0 ± 9.9
RCI 160 U/kg	612.5 ± 22.3	8.4 ± 5.3
RCI 400 U/kg	649.0 ± 25.6^b	13.3 ± 5.6^a,d
RCI 160 U/kg + ETN	634.5 ± 28.4^a	13.3 ± 5.4^a,d
RCI 400 U/kg + ETN	655.8 ± 25.7^b,d	15.2 ± 4.6^a,d

^a p ≤ 0.05 vs ETN alone group; ^b p ≤ 0.0001 vs ETN alone group; ^c p ≤ 0.0001 vs disease control group; ^d p ≤ 0.05 vs disease control group
Analyzed by 1-way ANOVA followed by the Holm-Sidak multiple comparisons test.
Abbreviations: ANOVA, analysis of variance; ETN, etanercept; mgHA, magnesium hydroxyapatite; RCI, repository corticotropin injection; SD, standard deviation

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