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Table 2 Bone density and cortical shell volume differences

From: Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept

Treatment Group Bone Density, Mean ± SD,
mgHA/cm3
Mature – New Bone
Volume, Mean ± SD, mm3
Naive 646.0 ± 17.8a 19.7 ± 1.7b,c
Disease control 628.5 ± 26.1 6.9 ± 7.2
ETN 10 mg/kg 605.9 ± 35.7 6.0 ± 9.9
RCI 160 U/kg 612.5 ± 22.3 8.4 ± 5.3
RCI 400 U/kg 649.0 ± 25.6b 13.3 ± 5.6a,d
RCI 160 U/kg + ETN 634.5 ± 28.4a 13.3 ± 5.4a,d
RCI 400 U/kg + ETN 655.8 ± 25.7b,d 15.2 ± 4.6a,d
  1. a p ≤ 0.05 vs ETN alone group; b p ≤ 0.0001 vs ETN alone group; c p ≤ 0.0001 vs disease control group; d p ≤ 0.05 vs disease control group
  2. Analyzed by 1-way ANOVA followed by the Holm-Sidak multiple comparisons test.
  3. Abbreviations: ANOVA, analysis of variance; ETN, etanercept; mgHA, magnesium hydroxyapatite; RCI, repository corticotropin injection; SD, standard deviation