Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Table 3 Association between CARMEN variants and ONFH risk

SNP-ID	Model	Genotype	Frequency		Without adjustment		With adjustment
SNP-ID	Model	Genotype	Case	Control	OR (95% CI)	p-value	OR (95% CI)	p-value
rs13177623	codominant	A/A	17	42	1		1
		A/G	133	178	0.96 (0.71–1.30)	0.794	0.95 (0.70–1.29)	0.726
		G/G	158	203	0.52 (0.29–0.95)	0.377	0.52 (0.28–0.94)	0.031
	dominant	A/A	17	42	1		1
		A/G-G/G	291	381	0.88 (0.65–1.18)	0.341	0.86 (0.64–1.16)	0.332
	recessive	A/A-A/G	150	220	1		1
		G/G	158	203	0.53 (0.30–0.95)	0.033	0.53 (0.30–0.95)	0.033
	log-additive	–	–	–	0.82 (0.65–1.04)	0.106	0.82 (0.65–1.03)	0.091
rs12654195	codominant	G/G	25	60	1		1
		G/T	142	174	1.05 (0.77–1.43)	0.771	1.04 (0.76–1.42)	0.831
		T/T	141	181	0.53 (0.32–0.90)	0.017	0.53 (0.32–0.90)	0.017
	dominant	G/G	25	60	1		1
		G/T-T/T	283	355	0.92 (0.68–1.23)	0.563	0.91 (0.67–1.22)	0.517
	recessive	G/G-G/T	167	234	1		1
		T/T	141	181	0.52 (0.32–0.85)	0.010	0.53 (0.32–0.86)	0.011
	log-additive	–	–	–	0.83 (0.66–1.03)	0.094	0.82 (0.66–1.03)	0.087

95%CI 95% Confidence interval; OR Odds ratio; SNP Single-nucleotide polymorphism
p-value: Calculated by Pearson χ² test
Bold type indicates statistical significance (p < 0.05)

ISSN: 1471-2474