The incidence of regression after the non-surgical treatment of symptomatic lumbar disc herniation: a systematic review and meta-analysis

Wang, Yi; Dai, Guogang; Jiang, Ling; Liao, Shichuan

doi:10.1186/s12891-020-03548-z

Table 1 Characteristics of the included studies

From: The incidence of regression after the non-surgical treatment of symptomatic lumbar disc herniation: a systematic review and meta-analysis

Author	Year	Country	Study type	Quality^a	LDH Level^b	Measurement	Imaging method	Counting^c	Number of patients
Author	Year	Country	Study type	Quality^a	LDH Level^b	Measurement	Imaging method	Counting^c	Regression	Total
El Barzouhi et al. [9]	2013	Netherlands	RCT	Low risk	single	Qualitative	MRI	A	88	95
Santilli et al. [10]	2006	Italy	RCT	Low risk	single/multiple	Qualitative	MRI	A	0	102
Fan et al. [11]	2015	China	RCT	Unclear risk	Unknow	Qualitative	MRI	A	0	158
Ahn et al. [12]	2002	Korea	Prospective	11	single	Qualitative	MRI	B	13	17
Maigne et al. [13]	1992	France	Prospective	10	single	Qualitative	CT	B	39	48
Benson et al. [14]	2010	UK	Prospective	12	single	Quantitative	MRI	B	28	32
Komori et al. [15]	1998	Japan	Retrospective	12	single	Qualitative	MRI	A	19	22
Modic et al. [16]	1995	USA	Prospective	12	single/multiple	Qualitative	MRI	B	4	16
Kamanli et al. [17]	2010	Turkey	Prospective	8	Unknown	Qualitative	MRI	A	5	26
Autio et al. [18]	2006	Finland	Prospective	12	single	Quantitative	MRI	A	51	55
Gallucci et al. [19]	1995	Italy	Prospective	10	Unknown	Qualitative	MRI	B	11	15
Ozturk et al. [20]	2006	Turkey	RCT	Low risk	single/multiple	Quantitative	CT	A	19	46
Ahn et al. [21]	2000	Korea	Prospective	12	single	Quantitative	MRI	A	25	36
Ilkko et al. [22]	1993	Finland	Unknown	7	single/multiple	Qualitative	CT	A	15	18
Delauche-Cavallier et al. [23]	1992	France	Prospective	9	single	Qualitative	CT	A	14	21
Buttermann et al. [24]	2002	USA	Prospective	10	single	Quantitative	MRI	A	52	58
Bozzao et al. [25]	1992	Italy	Prospective	10	Unknow	Qualitative	MRI	A	41	65
Broetz et al. [26]	2008	Germany	Prospective	9	Unknow	Qualitative	MRI	A	0	10
Jensen et al. [27]	2006	Denmark	Prospective	10	Unknow	Qualitative	MRI	A	65	139
Henmi et al. [28]	2002	Japan	Unknown	11	single	Quantitative	MRI	A	4	10
Takada et al. [29]	2001	Japan	Prospective	9	single	Qualitative	MRI	A	37	42
Cribb et al. [30]	2007	England	Unknown	7	single	Quantitative	MRI	A	14	15
Ellenberg et al. [31]	1993	USA	Prospective	9	single/multiple	Qualitative	CT	A	11	14
Demirel et al. [32]	2017	Turkey	RCT	Low risk	single/multiple	Quantitative	MRI	A	18	20
Hong et al. [33]	2016	Korea	Retrospective	10	single	Quantitative	MRI	A	24	28
Matsubara et al. [34]	1995	Japan	Unknown	9	single	Qualitative	MRI	B	20	32
Yukawa et al. [35]	1996	Japan	Unknown	11	single	Quantitative	MRI	A	17	30
Fagerlund et al. [36]	1990	Sweden	Prospective	12	single	Qualitative	CT	B	22	30
Kesikburun et al. [37]	2019	Turkey	Prospective	12	single	Quantitative	MRI	A	36	40
Teplick et al. [38]	1985	USA	Unknown	7	Unknown	Qualitative	CT	A	11	55
Shan et al. [39]	2014	China	Retrospective	12	single	Quantitative	MRI	A	24	30
Shin et al. [40]	2017	Korea	Prospective	8	Unknown	Qualitative	MRI	A	42	73
Komori et al. [41]	1996	Japan	Retrospective	10	single	Qualitative	MRI	A	49	77
Saal et al. [42]	1990	USA	Unknown	8	Unknown	Qualitative	CT/MRI	B	9	11
Bush et al. [43]	1992	UK	Prospective	10	single/multiple	Qualitative	CT	A	71	111
Iwabuchi et al. [44]	2010	Japan	Prospective	10	single	Qualitative	MRI	A	21	34
Yu et al. [45]	2014	China	Unknown	10	single	Qualitative	MRI	A	20	83
Lee et al. [46]	2017	Korea	Retrospective	10	single	Quantitative	MRI	A	486	505

^aQuality of non-randomized studies was assessed following the MINORS; the risk of bias of RCTs was evaluated using a tool from the Cochrane Collaboration
^bSome studies included only single-level SLDH patients and some studies included both single- and multiple-level SLDH patients
^cCounting. A. The number of patients with regression was reported and was extracted from the publication. B: For studies that recorded the number of patients by the regression proportion or size interval but did not define the interval of non-regression or report the number of patients without regression, we regarded the lowest interval as the no regression range, and the number of patients outside of this interval was considered the number of patients with regression

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