Table 1 The cases of quadruple primary neoplasms reported in the English literature between 2000 and 2020

Mussari [9], 2000

47/M

Anus/ Esophagus/ Lung/ Oral cavity

N/A

N/A

N/A

48/M

Lung/ Stomach/ Rectum/ Lung

N/A

N/A

N/A

55/M

Oral cavity/ Oropharynx/ Esophagus/ Melanoma

N/A

N/A

N/A

60/M

Oral cavity/ Larynx/ Lymphoma/ Esophagus

N/A

N/A

N/A

Noh [10], 2008

68/F

Breast cancer/ Rectal adenocarcinoma/ Ovary carcinoma/ Endometrium carcinoma

Metachronous

N/A

N/A

Angurana [11], 2010

35/F

Infiltrating duct cell carcinoma Breast carcinoma/ Early infiltrating duct cell carcinoma of breast carcinoma/ Adenocarcinoma endometrium/ Esophagus carcinoma

Metachronous

30 years

N/A

Jiao [12], 2013

64/M

Small intestine adenocarcinoma/ Colon adenocarcinoma/ Urothelial carcinoma of the pelvis/ Pancreatic cancer

Metachronous

20 years

N/A

KIM [13], 2013

73/F

Thyroid carcinoma/ Breast carcinoma/ Pancreatic carcinoma/ Gastrointestinal stromal tumor

Synchronous

8 months (DOD)

N/A

Milosevic [14], 2014

40/F

Medullary thyroid carcinoma/ Micropapillary thyroid carcinoma/ Melanoma/ Breast carcinoma

Metachronous

N/A

PTEN/P53 /RET/HRAS/KRAS

Kousaka [15], 2014

41/F

Osteosarcoma/ Tongue cancer/ Thyroid cancer/ Breast carcinoma

Metachronous

3 months

N/A

Grace [16], 2015

70/M

Glioblastoma/ Schwannoma/ Neuroendocrine tumor/ Adenoma

Synchronous

N/A

EGFR /CDKN2A/2B/PTEN

Meeks [17], 2016

95/F

Adenocarcinoma/ Adenoma/ Neuroendocrine tumor/ Schwann cell hamartoma

Synchronous

N/A

N/A

Elec [18], 2017

78/M

Prostate adenocarcinoma/ Clear-cell renal carcinoma/ Papillary renal carcinoma/ Bladder cancer

Synchronous

4 years

N/A

Nanashima [19], 2017

67/M

Stomach/ Sigmoid colon/ Rectum/ Pancreas carcinomas

Synchronous

4.25 years

N/A

Wang [20], 2019

56/F

Cervix/ Endometrium/ Ovary/ Stomach carcinomas

Synchronous

1 year

N/A