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Table 2 Longitudinal Change in Cumulative Damage and Disease Activity From Two to One Year Prior to the Index Visit is Associated with Accelerated Knee Osteoarthritis (AKOA) Development

From: Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

 Knee Osteoarthritis (KOA) GroupOR (95% Confidence Interval)a
OR per unit of SDb
1-Year Change in Composite MetricsAccelerated
(n = 87)
Mean (SD)
Typical
(n = 64)
Mean (SD)
No
(n = 96)
Mean (SD)
Accelerated vs Typical KOA (REF)Accelerated vs No KOA (REF)
Cumulative Damage0.34 (0.70)0.10 (0.44)0.01 (0.55)1.69
(1.14–2.51)^
2.11
(1.41–3.16)^
Disease Activity1.49 (3.20)0.61 (1.72)0.06 (1.52)1.58
(1.08–2.33)^
2.39
(1.55–3.71)^
  1. OR odds ratio,
  2. aAdjusted for age, BMI, sex, race, WOMAC pain, KL grade, and pain medication at the visit 2 years prior to the index visit
  3. b Odds ratios are reported as increased odds for developing accelerated knee osteoarthritis per entire group standard deviation for one-year change in cumulative damage (i.e., 0.60) and disease activity (i.e., 2.37)
  4. ^Statistically significant (p< 0.05)