Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

Table 2 Longitudinal Change in Cumulative Damage and Disease Activity From Two to One Year Prior to the Index Visit is Associated with Accelerated Knee Osteoarthritis (AKOA) Development

	Knee Osteoarthritis (KOA) Group			OR (95% Confidence Interval)^a OR per unit of SD^b
1-Year Change in Composite Metrics	Accelerated (n = 87) Mean (SD)	Typical (n = 64) Mean (SD)	No (n = 96) Mean (SD)	Accelerated vs Typical KOA (REF)	Accelerated vs No KOA (REF)
Cumulative Damage	0.34 (0.70)	0.10 (0.44)	0.01 (0.55)	1.69 (1.14–2.51)^	2.11 (1.41–3.16)^
Disease Activity	1.49 (3.20)	0.61 (1.72)	0.06 (1.52)	1.58 (1.08–2.33)^	2.39 (1.55–3.71)^

OR odds ratio,
^aAdjusted for age, BMI, sex, race, WOMAC pain, KL grade, and pain medication at the visit 2 years prior to the index visit
^b Odds ratios are reported as increased odds for developing accelerated knee osteoarthritis per entire group standard deviation for one-year change in cumulative damage (i.e., 0.60) and disease activity (i.e., 2.37)
^Statistically significant (p< 0.05)

ISSN: 1471-2474