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Table 2 Longitudinal Change in Cumulative Damage and Disease Activity From Two to One Year Prior to the Index Visit is Associated with Accelerated Knee Osteoarthritis (AKOA) Development

From: Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

 Knee Osteoarthritis (KOA) GroupOR (95% Confidence Interval)a
OR per unit of SDb
1-Year Change in Composite MetricsAccelerated
(n = 87)
Mean (SD)
(n = 64)
Mean (SD)
(n = 96)
Mean (SD)
Accelerated vs Typical KOA (REF)Accelerated vs No KOA (REF)
Cumulative Damage0.34 (0.70)0.10 (0.44)0.01 (0.55)1.69
Disease Activity1.49 (3.20)0.61 (1.72)0.06 (1.52)1.58
  1. OR odds ratio,
  2. aAdjusted for age, BMI, sex, race, WOMAC pain, KL grade, and pain medication at the visit 2 years prior to the index visit
  3. b Odds ratios are reported as increased odds for developing accelerated knee osteoarthritis per entire group standard deviation for one-year change in cumulative damage (i.e., 0.60) and disease activity (i.e., 2.37)
  4. ^Statistically significant (p< 0.05)