Fig. 8From: Pre-operative denosumab is associated with higher risk of local recurrence in giant cell tumor of bone: a systematic review and meta-analysisa-c This shows a patient with a proximal humerus GCT with (a) a radiograph at presentation who was treated with eight injections of denosumab, which led to (b) bony shell formation and sclerosis within the lesion after which the patient underwent intralesional surgery for disease clearance. Eight months postoperatively the patient presented with a local recurrence, which as seen on (c) radiography and MRI suggested aggressive malignant transformation. Biopsy confirmed osteosarcomaBack to article page