Measurement | Baseline | Injection | 2 weeks fu | 4 weeks fu | 8 weeks fu | 12 weeks fu | 24 weeks fu |
---|---|---|---|---|---|---|---|
Primary outcome measure | |||||||
 KOOS pain subscale | x |  | x | x | x | x | x |
Secondary outcome measures | |||||||
 Adverse events |  |  | x |  |  |  |  |
 Hospitalization |  |  | x | x | x | x | x |
 Co-interventions (iMCQ) |  |  | x | x | x | x | x |
 Medication use for knee OA | x |  | x | x | x | x | x |
 Re-injection with glucocorticoid |  |  |  |  | x | x | x |
 KOOS stiffness | x |  | x | x | x | x | x |
 KOOS function in daily living | x |  | x | x | x | x | x |
 KOOS sports and recreation | x |  | x | x | x | x | x |
 KOOS QoL | x |  | x | x | x | x | x |
 ICOAP | x |  | x | x | x | x | x |
 OMERACT OARSI responder criteria |  |  | x | x | x | x | x |
 Knee pain over past week (NRS) | x | x | x | x | x | x | x |
 Perceived recovery (Likert scale) |  |  | x | x | x | x | x |
 Knee complaint characteristics | x |  | x | x | x | x | x |
 Health related QoL | x |  |  |  |  |  |  |
Additional measurements | |||||||
 Radiograph of study knee |  |  |  |  |  | x |  |
 Check of ACR criteria |  | x |  |  |  |  |  |
 Painfulness of injection (NRS) |  |  | x |  |  |  |  |
 Demographic information | x |  |  |  |  |  |  |
 Co-morbidity | x |  |  |  |  |  |  |
 Physical activity over the past week (IPAQ short) | x |  |  |  |  |  |  |
 Neuropathic pain (Modified painDETECT Questionnaire) | x |  |  |  |  |  |  |
 Patients’ preferred injection site | x |  |  |  |  |  |  |
 Patients’ expected treatment response | x |  |  |  |  |  |  |