Fig. 1

Clinical manifestations of patient. a Personal and family history of the Vietnamese family presenting with MED. Squares denote males, circles denote females. b, c, d. Radiographs of the patient. The patient has a varus deformity of the lower limbs. Her limb lengths were lower than average: her femur was 33 cm long (b), and her tibia was 30 cm (c). The patient had abnormal cartilage development at the epiphysis of the femur and patella. Ossification occurred prematurely at the epiphyseal plates. The metaphysis of the femur and patella was deformed and flatten; the femur condyle was shorten. No deformity was detected in her feet (d)