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Table 4 Allele and genotype distribution between patients with different severity of IS

From: CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Allele/genotypeCobb angle ≤ 30° N = 87Cobb angle ≥ 35° N = 118Independent model P-valueP-valueOR (CI 0.95)
rs1017861
 G93.783.5 0.0030a2.93 (1.46–5.91)
 A6.316.5
 GG88.569.50.00550.64b2.24 (0.23–21.95)
 GA10.328.0  
 AA1.22.50.0022c3.38 (1.6–7.27)
rs4738824
 G83.380.5 0.55a1.21 (0.72–2.02)
 A16.719.5
 GG68.963.60.650.91b1.1 (0.18–6.78)
 GA28.733.9  
 AA2.32.50.51c1.27 (0.71–2.29)
rs4738813
 T63.275.4 0.0104a0.56 (0.36–0.86)
 C36.824.6
 TT40.256.80.02210.0506b0.36 (0.14–0.94)
 CT44.837.3  
 CC14.95.90.0277c0.51 (0.29–0.89)
  1. Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: a – alleles, b – dominant model, c – recessive model
  2. significant P-values (<0.05) are in bold