CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Table 4 Allele and genotype distribution between patients with different severity of IS

Allele/genotype	Cobb angle ≤ 30° N = 87	Cobb angle ≥ 35° N = 118	Independent model P-value	P-value	OR (CI 0.95)
rs1017861
G	93.7	83.5		0.0030^a	2.93 (1.46–5.91)
A	6.3	16.5		0.0030^a	2.93 (1.46–5.91)
GG	88.5	69.5	0.0055	0.64^b	2.24 (0.23–21.95)
GA	10.3	28.0
AA	1.2	2.5		0.0022^c	3.38 (1.6–7.27)
rs4738824
G	83.3	80.5		0.55^a	1.21 (0.72–2.02)
A	16.7	19.5		0.55^a	1.21 (0.72–2.02)
GG	68.9	63.6	0.65	0.91^b	1.1 (0.18–6.78)
GA	28.7	33.9
AA	2.3	2.5		0.51^c	1.27 (0.71–2.29)
rs4738813
T	63.2	75.4		0.0104^a	0.56 (0.36–0.86)
C	36.8	24.6		0.0104^a	0.56 (0.36–0.86)
TT	40.2	56.8	0.0221	0.0506^b	0.36 (0.14–0.94)
CT	44.8	37.3
CC	14.9	5.9		0.0277^c	0.51 (0.29–0.89)

Abbreviations: IS idiopathic scoliosis, OR odds ratio, CI 95% confidence interval, P-value for: ^a – alleles, ^b – dominant model, ^c – recessive model
significant P-values (<0.05) are in bold

ISSN: 1471-2474