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Table 2 Characteristics of the Included Studies

From: Risk factors associated with osteonecrosis of femoral head after internal fixation of femoral neck fracture:a systematic review and meta-analysis

Included studies

Study design

Country

Studycharacteristics

Follow up (months)

Factors

NOS score

Wang T 2014 [16]

Case–control

China

61 males, 18–68 y

6–90

Age, sex,Garden classification, reduction quality,reduction methods, injury-operationinterval, preoperative traction, weight-bearingtime, implant removal

9

Khoo CCH 2014 [17]

Case–control

Malaysia

39 males, 30–59 y

Unclear

Age, injury-operationinterval, fracture location, integrity of posterior cortex, adequacy of fracture reduction

6

Kang JS 2016 [18]

Case–control

Korea

Unclear, 16–18 y

24–148

Age, injury-operationinterval, osteoporosis, displacement, quality of reduction, firm fixation

6

Wang C 2015 [19]

Case–control

China

62 males, 51.9 ± 9.9 y

34–41

Age, gender, length of stay, fracture laterality, mechanismof injury, procedure delay, duration of surgery, implantconfiguration, interval to full weight-bearing, preoperativeGarden classification, preoperative traction, postoperativevisual analog scale (VAS), Parker score, implant status,residual displacement

8

Zhang C 2017 [20]

Case–control

China

Unclear, 50–70 y

36–48

Age, sex, ASA scale, laterality (L/R), body mass index (BMI), BMD, Garden classification, Bone mineral density, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B)

6

Schweitzer D 2013 [21]

Case–control

Chile

22 males, 46.45 ± 11.59y

24–144

Age, injury-operation interval, anatomicreduction, mechanism of injury, fracture reduction mode

9

Simona P 2008 [22]

Case–control

France

Unclear

Unclear

Garden classification, Pauwels classification

6

Ai ZS 2013 [23]

Case–control

China

44 males, >  45 y

28–60

Age, gender, type of fracture(Garden classification), timing of the reduction, quality ofthe reduction (Garden classification), postoperative durationto full weight bearing, implant status (removal vs. maintenance),preoperative traction, fracture side

8

Wang CT 2018 [24]

Case–control

Taiwan, China

43 males, 50–60 y

12–96

Garden classification, reduction quality,Pauwels classification

6

Zeng XS 2017 [25]

Case–control

China

142 males, 50–94 y

37–46

Age, sex, ASA scale, laterality (L/R), BMI, FNBMD, Garden classification, Garden index, injury-operation interval, weight-bearing activity time, TC, TG, HDL, LDL, Apo-A1, Apo-B

9

Koaban S 2019 [26]

Case–control

Saudi Arabia

60 males, 18–70 y

> 13

Gender, presence of comorbid conditions, mode of injury, multiple trauma, Garden classification,fracture side, time of fixation, type of reduction, full weight-bearing follow-up

9

Razik F 2012 [27]

Case–control

UK

Unclear

Unclear

Fracture side, time of fixation, fracture classification, mechanism, complications, method of fixation

7

Schwartsmann CR 2014 [28]

Case–control

Brazil

56 males, 18–70 y

64.6

Sex, age, Garden grade,time of surgery, reduction

7

Zhang YL 2016 [29]

Case–control

China

 

21.6 ± 6.0

Garden types

6

Jo S 2016 [30]

Case–control

Korea

25 males, 16–69 y

24–75

Anatomical classification, Garden classification, Pauwels classification

6

Zhao HX 2016 [31]

Case–control

China

61 males, >  18 y

21.6 ± 6.0

Sex, age, Garden grade, time of surgery, Garden index

7

Mao YJ 2005 [32]

Case–control

China

134 males, 13–70 y

12–101

Sex, age, Garden classification, reduction quality, injury-operationinterval, preoperative traction, weight-bearingtime, implant removal, fracture reduction mode

9

  1. ASA American Society of Anesthesiologists; BMD Bone mineral density; TC Total Cholesterol; TG Triglyceride; HDL High Density Lipoprotein; LDL Low Density Lipoprotein; Apo-A1 Apolipoprotein A1; Apo-B Apolipoprotein B; BMI body mass index; FNBMD femoral neck bone mineral density