Hip replacement | Knee replacement | All patients | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
n (% [95% CI]) | n (% [95% CI]) | p-value | Female n (% [95% CI]) | Male n (% [95% CI]) | p-value | Age < 65 years n (% [95% CI]) | Age 65–75 years n (% [95% CI]) | Age > 75 years n (% [95% CI]) | p-value | |
N | 6238 | 7501 | 8396 | 5343 | 4817 | 4807 | 4115 | |||
Any analgesic drug | ||||||||||
21–24 months preop | 1771 (28.4% [27.3–29.5]) | 2456 (32.7%[31.7–33.8]) | < 0.001 | 2766 (32.9% [31.9–34.0]) | 1461 (27.3% [26.2–28.5]) | < 0.001 | 1472 (30.6% [29.3–31.9]) | 1436 (29.9% [28.6–31.2]) | 1319 (32.1% [30.6–33.5]) | 0.078 |
0–3 months preop | 3013 (48.3% [47.1–49.5]) | 3045 (40.6% [39.5–41.7]) | < 0.001 | 3862 (46.0% [44.9–47.1]) | 2196 (41.1% [39.8–42.4]) | < 0.001 | 2162 (44.9% [43.5–46.3]) | 2135 (44.4% [43.0–45.8]) | 1761 (42.8% [41.3–44.3]) | 0.120 |
21–24 months postop | 1429 (22.9% [21.9–24.0]) | 2253 (30.0% [29.0–31.1]) | < 0.001 | 2539 (30.2% [29.3–31.2]) | 1143 (21.4% [20.3–22.5]) | < 0.001 | 1226 (25.5% [24.2–26.7]) | 1254 (26.1% [24.9–27.3]) | 1202 (29.2% [27.8–30.6]) | < 0.001 |
Acetaminophen | ||||||||||
21–24 months preop | 277 (4.4%[3.9–5.0]) | 390 (5.2% [4.7–5.7]) | 0.039 | 487 (5.8% [5.3–6.3]) | 180 (3.4% [2.9–3.9]) | < 0.001 | 161 (3.3% [2.8–3.9]) | 222 (4.6% [4.0–5.2]) | 284 (6.9% [6.1–7.7]) | < 0.001 |
0–3 months preop | 870 (13.9% [13.1–14.8]) | 894 (11.9% [11.2–12.7]) | < 0.001 | 1203 (14.3% [13.6–15.1]) | 561 (10.5% [9.7–11.3]) | < 0.001 | 439 (9.1% [8.3–9.9]) | 628 (13.1% [12.1–14.0]) | 697 (16.9% [15.8–18.1]) | < 0.001 |
21–24 months postop | 546 (8.8% [8.1–9.5]) | 857 (11.4% [10.7–12.2]) | < 0.001 | 1023 (12.2% [11.5–12.9]) | 380 (7.1% [6.4–7.8]) | < 0.001 | 313 (6.5% [5.8–7.2]) | 462 (9.6% [8.8–10.4]) | 628 (15.3% [14.2–16.4]) | < 0.001 |
NSAID | ||||||||||
21–24 months preop | 1387 (22.2% [21.1–23.3]) | 1916 (25.5% [24.6–26.5]) | < 0.001 | 2125 (25.3% [24.4–26.2]) | 1178 (22.0% [20.9–23.2]) | < 0.001 | 1224 (25.4% [24.2–26.6]) | 1139 (23.7% [22.5–24.9]) | 940 (22.8% [21.6–24.1]) | 0.014 |
0–3 months preop | 2095 (33.6% [32.4–34.8]) | 1983 (26.4% [25.4–27.4]) | < 0.001 | 2544 (30.3% [29.3–31.3]) | 1534 (28.7% [27.5–29.9]) | 0.047 | 1664 (34.5% [33.2–35.9]) | 1455 (30.3% [30.0–31.6]) | 959 (23.3% [22.0–24.6]) | < 0.001 |
21–24 months postop | 749 (12.0% [11.2–12.8]) | 1168 (15.6% [14.8–16.4]) | < 0.001 | 1276 (15.2% [14.4–16.0]) | 641 (12.0% [11.1–12.9]) | < 0.001 | 803 (16.7% [15.6–17.7]) | 675 (14.0% [13.1–15.0]) | 439 (10.7% [9.7–11.6]) | < 0.001 |
Mild opioid | ||||||||||
21–24 months preop | 266 (4.3% [3.8–4.8]) | 397 (5.3% [4.8–5.8]) | 0.005 | 431 (5.1% [4.7–5.6]) | 232 (4.3% [3.8–4.9]) | 0.035 | 233 (4.8%4.2–5.4]) | 224 (4.7% [4.1–5.3]) | 206 (5.0% [4.3–5.7]) | 0.748 |
0–3 months preop | 850 (13.6% [12.8–14.5]) | 660 (8.8% [8.2–9.4]) | < 0.001 | 963 (11.5% [10.8–12.2]) | 547 (10.2% [9.4–11.1]) | 0.024 | 588 (12.2% [11.3–13.1]) | 488 (10.2% [9.3–11.0]) | 434 (10.5% [9.6–11.5]) | 0.003 |
21–24 months postop | 334 (5.4% [4.8–5.9]) | 571 (7.6% [7.0–8.2]) | < 0.001 | 631 (7.5% [7.0–8.1]) | 274 (5.1% [4.5–5.7]) | < 0.001 | 295 (6.1% [5.5–6.8]) | 305 (6.3% [5.7–7.0]) | 305 (7.4% [6.6–8.2]) | 0.035 |
Strong opioid | ||||||||||
21–24 months preop | 7 (0.1% [0.03–0.2]) | 25 (0.3% [0.2–0.5]) | 0.007 | 23 (0.3% [0.2–0.4]) | 9 (0.2% [0.1–0.3]) | 0.211 | 10 (0.2% [0.1–0.3]) | 10 (0.2% [0.1–0.3]) | 12 (0.3% [0.1–0.5]) | 0.647 |
0–3 months preop | 29 (0.5% [0.3–0.6]) | 29 (0.4% [0.3–0.5]) | 0.481 | 35 (0.4% [0.3–0.6]) | 23 (0.4% [0.3–0.6]) | 0.905 | 18 (0.4% [0.2–0.6]) | 22 (0.5% [0.3–0.7]) | 18 (0.4% [0.2–0.6]) | 0.804 |
21–24 months postop | 15 (0.2% [0.1–0.4]) | 31 (0.4% [0.3–0.6]) | 0.081 | 35 (0.4% [0.3–0.6) | 11 (0.2% [0.1–0.3]) | 0.037 | 12 (0.2% [0.1–0.4]) | 16 (0.3% [0.2–0.5]) | 18 (0.4% [0.2–0.6]) | 0.307 |
Medication used for neuropathic pain | ||||||||||
21–24 months preop | 144 (2.3% [1.9–2.7]) | 233 (3.1% [2.7–3.5]) | 0.004 | 290 (3.5% [3.1–3.8]) | 87 (1.6% [1.3–2.0]) | < 0.001 | 145 (3.0% [2.5–3.5]) | 126 (2.6% [2.2–3.1]) | 106 (2.6% [2.1–3.1]) | 0.370 |
0–3 months preop | 192 (3.1% [2.7–3.5]) | 262 (3.5% [3.1–3.9]) | 0.176 | 334 (4.0% [3.6–4.4]) | 120 (2.2% [1.9–2.6]) | < 0.001 | 184 (3.8% [3.3–4.4]) | 154 (3.2% [2.7–3.7]) | 116 (2.8% [2.3–3.3]) | 0.027 |
21–24 months postop | 181 (2.9% [2.5–3.3]) | 317 (4.2% [3.8–4.7]) | < 0.001 | 370 (4.4% [4.0–4.9) | 128 (2.4% [2.0–2.8]) | < 0.001 | 175 (3.6% [3.1–4.2]) | 165 (3.4% [2.9–4.0]) | 158 (3.8% [3.3–4.4]) | 0.591 |