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Table 2 Baseline Pre-Radiographic Structural Features Associated with Accelerated Knee Osteoarthritis (OA) Over the Next 4 Years

From: Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Structural Feature Group
AKOA (n = 113) No AKOA (Reference, n = 241) Univariate Odds Ratio
n (%) n (%) OR (95% CI)
Semi-Quantitative Degenerative Cruciate Ligaments Absence 66 (58%) 181 (75%) Reference
Presence 47 (42%) 60 (25%) 2.15 (1.34, 3.45)*
Degenerative Collateral Ligaments Absence 88 (78%) 206 (85%) Reference
Presence 25 (22%) 35 (15%) 1.67 (0.95, 2.96)
Degenerative Extensor Mechanism Absence 64 (57%) 163 (68%) Reference
Presence 49 (43%) 78 (32%) 1.60 (1.01, 2.53)
Degenerative Gastrocnemius Tendon Absence 64 (57%) 146 (61%) Reference
Presence 49 (43%) 95 (39%) 1.18 (0.75, 1.85)
Infrapatellar Fat Pad Signal Intensity Alteration Absence 63 (56%) 172 (71%) Reference
Presence 50 (44%) 69 (29%) 1.98 (1.24, 3.15)*
Medial Meniscal Pathology Absence 35 (31%) 118 (49%) Reference
Presence 78 (69%) 123 (51%) 2.14 (1.33, 3.43)*
Lateral Meniscal Pathology Absence 64 (57%) 182 (76%) Reference
Presence 49 (43%) 59 (24%) 2.36 (1.47, 3.79)*
Medial Meniscal Extrusion Absence 90 (80%) 210 (87%) Reference
Presence 23 (20%) 31 (13%) 1.73 (0.96, 3.13)
Lateral Meniscal Extrusion Absence 109 (96%) 238 (99%) Reference
Presence 4 (4%) 3 (1%) 2.91 (0.64, 13.23)
Quantitative Effusion-Synovitis Volume^ Smallest 63 (56%) 176 (73%) Reference
Largest 50 (44%) 65 (27%) 2.15 (1.35, 3.43)*
Bone Marrow Lesion Volume^ Smallest 78 (69%) 161 (67%) Reference
Largest 35 (31%) 80 (33%) 0.90 (0.56, 1.46)
Cartilage Damage Index^ Largest 79 (70%) 159 (66%) Reference
Smallest 34 (30%) 82 (34%) 0.84 (0.52, 1.35)
  1. *Statistically significant: p < 0.004. ^Comparing the worst tertile (i.e. largest effusion-synovitis /bone marrow lesion, smallest CDI) to the other 2 tertiles