Table 2 Baseline Pre-Radiographic Structural Features Associated with Accelerated Knee Osteoarthritis (OA) Over the Next 4 Years
From: Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis
Structural Feature | Group | ||||
|---|---|---|---|---|---|
AKOA (n = 113) | No AKOA (Reference, n = 241) | Univariate Odds Ratio | |||
n (%) | n (%) | OR (95% CI) | |||
Semi-Quantitative | Degenerative Cruciate Ligaments | Absence | 66 (58%) | 181 (75%) | Reference |
Presence | 47 (42%) | 60 (25%) | 2.15 (1.34, 3.45)* | ||
Degenerative Collateral Ligaments | Absence | 88 (78%) | 206 (85%) | Reference | |
Presence | 25 (22%) | 35 (15%) | 1.67 (0.95, 2.96) | ||
Degenerative Extensor Mechanism | Absence | 64 (57%) | 163 (68%) | Reference | |
Presence | 49 (43%) | 78 (32%) | 1.60 (1.01, 2.53) | ||
Degenerative Gastrocnemius Tendon | Absence | 64 (57%) | 146 (61%) | Reference | |
Presence | 49 (43%) | 95 (39%) | 1.18 (0.75, 1.85) | ||
Infrapatellar Fat Pad Signal Intensity Alteration | Absence | 63 (56%) | 172 (71%) | Reference | |
Presence | 50 (44%) | 69 (29%) | 1.98 (1.24, 3.15)* | ||
Medial Meniscal Pathology | Absence | 35 (31%) | 118 (49%) | Reference | |
Presence | 78 (69%) | 123 (51%) | 2.14 (1.33, 3.43)* | ||
Lateral Meniscal Pathology | Absence | 64 (57%) | 182 (76%) | Reference | |
Presence | 49 (43%) | 59 (24%) | 2.36 (1.47, 3.79)* | ||
Medial Meniscal Extrusion | Absence | 90 (80%) | 210 (87%) | Reference | |
Presence | 23 (20%) | 31 (13%) | 1.73 (0.96, 3.13) | ||
Lateral Meniscal Extrusion | Absence | 109 (96%) | 238 (99%) | Reference | |
Presence | 4 (4%) | 3 (1%) | 2.91 (0.64, 13.23) | ||
Quantitative | Effusion-Synovitis Volume^ | Smallest | 63 (56%) | 176 (73%) | Reference |
Largest | 50 (44%) | 65 (27%) | 2.15 (1.35, 3.43)* | ||
Bone Marrow Lesion Volume^ | Smallest | 78 (69%) | 161 (67%) | Reference | |
Largest | 35 (31%) | 80 (33%) | 0.90 (0.56, 1.46) | ||
Cartilage Damage Index^ | Largest | 79 (70%) | 159 (66%) | Reference | |
Smallest | 34 (30%) | 82 (34%) | 0.84 (0.52, 1.35) | ||