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Table 1 Information of donors and intervertebral discs used in this study

From: Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration

Patient # Age Gender Number of IVDs MRI Grade
(disc level)
Experimental Protocol #
1 35–39 Male 2 2 (L1/2, L2/3) 1, 2, 5
2 35–39 Male 2 2 (T12/L1, L1/2) 1, 2
3 65–69 Male 2 4 (L3/4, L4/5) 1, 2
4 75–79 Female 1 5 (L3/4) 1
5 65–69 Male 2 4 (L3/4, L4/5) 1
6 25–29 Male 2 2 (L4/5, L5/S1) 2
7 65–69 Female 4 4 (L2/3, L4/5), 5 (L3/4), 3 (L5/S1) 2
8 80–84 Female 1 4 (L4/5) 3
9 70–74 Female 4 4 (L1/2-L4/5) 3
10 75–79 Female 3 4 (L2/3-L4/5) 3
11 65–69 Male 1 4 (L4/5) 3
12 75–79 Female 2 3 (L1/2), 4 (L4/5) 3
13 80–84 Female 2 4 (L3/4, L4/5) 4
14 70–74 Female 2 4 (T12/L1, L1/2) 4
15 50–54 Male 1 4 (L4/5) 4
16 65–69 Female 4 4 (L2/3-L5/S1) 4
17 75–79 Female 2 4 (L4/5, L5/S1) 4
18 70–74 Female 1 4 (L4/5) 4
19 75–79 Female 2 4 (L3/4, L4/5) 1, 4
20 40–44 Male 1 2 (L4/5) 4
21 55–59 Male 3 3 (L2/3, L3/4), 4 (L4/5) 4
22 65–69 Female 2 3 (L3/4), 4 (L4/5) 4
23 65–69 Male 1 4 (L5/S1) 4
24 80–84 Female 2 4 (L3/4, L4/5) 4
  1. Experimental protocols: 1. Effect of IL-1β stimulation on mRNA levels of RANK/RANKL/OPG; 2. Effect of RANKL on the expression of proinflammatory cytokines and matrix-degrading enzymes with or without IL-1β stimulation; 3. Effect of OPG on the expression of proinflammatory cytokines and matrix-degrading enzymes with or without IL-1β stimulation; 4. Effect of anti-human RANKL antibody on the expression of proinflammatory cytokines and matrix-degrading enzymes with or without IL-1β stimulation; and 5. Immunofluorescent analysis of human IVD cells