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Fig. 7 | BMC Musculoskeletal Disorders

Fig. 7

From: Antibiotic-impregnated articulating cement spacer maintained for 7 years in situ for two-stage primary total knee arthroplasty: a case report

Fig. 7

Photomicrograph of foreign body granulation tissue showing variable sizes of negative patterns of polymethyl methacrylate (PMMA) particles surrounded by giant cells and macrophages. PMMA particles are well known to dissolve during normal preparation for paraffin embedding. Tiny particles were assumed to be abraded X-ray contrast medium used as an ingredient in bone cement. They were accumulated in phagocytes with sizes ranging from 0.5 to 1 μm in diameter. Marked fibrous tissue surrounding the inflammatory cells could be observed (hematoxylin and eosin staining; original magnification, × 400)

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