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Table 3 Risk of vertebral fracture for patients with stroke according to thiazide and loop diuretic use

From: Association between diuretic use and the risk of vertebral fracture after stroke: a population-based retrospective cohort study

  Thiazide use Loop diuretic use
Yes (n = 4734) No (n = 4734) Yes (n = 2364) No (n = 2364)
Cases of vertebral fracture 138 108 99 67
Person-years 8975.9 8251.3 3928.8 3740.5
Incidence ratea 15.4 13.1 25.2 17.9
Univariate model
 crude HR (95% CI) 1.18 (0.92–1.52) 1 (ref.) 1.40 (1.03–1.92) 1 (ref.)
p value 0.201   0.032  
Multivariate modelb
 adjusted HR (95% CI) 1.14 (0.88–1.47) 1 (ref.) 1.45 (1.06–1.98) 1 (ref.)
p value 0.316   0.019  
  1. aPer 1000 person-years
  2. bMultivariate Cox proportional hazard regression model with adjustment for all baseline characteristics shown in Table 1
  3. Abbreviations: HR hazard ratio, CI confidence interval