|
Thiazide use
|
Loop diuretic use
|
---|
Yes (n = 4734)
|
No (n = 4734)
|
Yes (n = 2364)
|
No (n = 2364)
|
---|
Cases of vertebral fracture
|
138
|
108
|
99
|
67
|
Person-years
|
8975.9
|
8251.3
|
3928.8
|
3740.5
|
Incidence ratea
|
15.4
|
13.1
|
25.2
|
17.9
|
Univariate model
|
crude HR (95% CI)
|
1.18 (0.92–1.52)
|
1 (ref.)
|
1.40 (1.03–1.92)
|
1 (ref.)
|
p value
|
0.201
| |
0.032
| |
Multivariate modelb
|
adjusted HR (95% CI)
|
1.14 (0.88–1.47)
|
1 (ref.)
|
1.45 (1.06–1.98)
|
1 (ref.)
|
p value
|
0.316
| |
0.019
| |
- aPer 1000 person-years
- bMultivariate Cox proportional hazard regression model with adjustment for all baseline characteristics shown in Table 1
- Abbreviations: HR hazard ratio, CI confidence interval