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Table 3 Risk of vertebral fracture for patients with stroke according to thiazide and loop diuretic use

From: Association between diuretic use and the risk of vertebral fracture after stroke: a population-based retrospective cohort study

 

Thiazide use

Loop diuretic use

Yes (n = 4734)

No (n = 4734)

Yes (n = 2364)

No (n = 2364)

Cases of vertebral fracture

138

108

99

67

Person-years

8975.9

8251.3

3928.8

3740.5

Incidence ratea

15.4

13.1

25.2

17.9

Univariate model

 crude HR (95% CI)

1.18 (0.92–1.52)

1 (ref.)

1.40 (1.03–1.92)

1 (ref.)

 p value

0.201

 

0.032

 

Multivariate modelb

 adjusted HR (95% CI)

1.14 (0.88–1.47)

1 (ref.)

1.45 (1.06–1.98)

1 (ref.)

 p value

0.316

 

0.019

 
  1. aPer 1000 person-years
  2. bMultivariate Cox proportional hazard regression model with adjustment for all baseline characteristics shown in Table 1
  3. Abbreviations: HR hazard ratio, CI confidence interval