Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population

Oura, Petteri; Hautala, Arto; Kiviniemi, Antti; Auvinen, Juha; Puukka, Katri; Tulppo, Mikko; Huikuri, Heikki; Seppänen, Tapio; Karppinen, Jaro

doi:10.1186/s12891-019-2426-2

BMC Musculoskeletal Disorders

Table 2 Primary Analysis. Results from sex-stratified linear regression models regarding the association between musculoskeletal pain sites (NPS) and cardiovascular autonomic function (HR, rMSSD, SBPV, BRS) in the full sample (for HR and rMSSD, n = 1813 men and 2373 women; for SBPV and BRS, n = 919 men and 1112 women). The complete models are presented in Additional files 4 and 5

From: Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population

	Model I	Model II	Model III	Model IV
	β for NPS [95% CI]	β for NPS [95% CI]	β for NPS [95% CI]	β for NPS [95% CI]
Men
Outcome: HR, seated	0.125 [−0.140; 0.391]	− 0.117 [− 0.374; 0.139]	−0.016 [− 0.288; 0.256]	−0.184 [− 0.447; 0.079]
Outcome: HR, standing	0.188 [− 0.105; 0.481]	− 0.015 [− 0.304; 0.274]	0.036 [− 0.265; 0.337]	− 0.099 [− 0.395; 0.197]
Outcome: rMSSD, seated	− 0.010 [− 0.024; 0.004]	0.002 [− 0.011; 0.016]	−0.005 [− 0.019; 0.010]	0.004 [− 0.010; 0.018]
Outcome: rMSSD, standing	− 0.011 [− 0.025; 0.003]	0.000 [− 0.014; 0.014]	− 0.005 [− 0.019; 0.009]	0.002 [− 0.012; 0.016]
Outcome: SBPV, seated	− 0.001 [− 0.026; 0.024]	0.000 [− 0.025; 0.026]	0.006 [− 0.020; 0.032]	0.005 [− 0.021; 0.032]
Outcome: SBPV, standing	− 0.014 [− 0.039; 0.011]	− 0.012 [− 0.038; 0.014]	0.001 [− 0.025; 0.027]	− 0.001 [− 0.027; 0.026]
Outcome: BRS, seated	− 0.002 [− 0.019; 0.015]	0.011 [− 0.005; 0.027]	0.003 [− 0.015; 0.020]	0.013 [− 0.004; 0.029]
Outcome: BRS, standing	− 0.001 [− 0.019; 0.016]	0.011 [− 0.006; 0.028]	0.003 [− 0.015; 0.021]	0.013 [− 0.005; 0.030]
Women
Outcome: HR, seated	0.318 [0.119; 0.516]	0.179 [− 0.017; 0.375]	0.230 [0.024; 0.437]	0.147 [− 0.055; 0.350]
Outcome: HR, standing	0.299 [0.066; 0.531]	0.203 [−0.029; 0.435]	0.256 [0.014; 0.498]	0.196 [−0.044; 0.436]
Outcome: rMSSD, seated	−0.020 [− 0.032; − 0.009]	−0.011 [− 0.022; − 0.000]	−0.011 [− 0.023; 0.001]	−0.006 [− 0.017; 0.006]
Outcome: rMSSD, standing	− 0.016 [− 0.027; − 0.004]	−0.009 [− 0.020; 0.003]	−0.008 [− 0.020; 0.004]	−0.004 [− 0.016; 0.008]
Outcome: SBPV, seated	− 0.001 [− 0.024; 0.022]	0.000 [− 0.023; 0.023]	0.003 [− 0.021; 0.027]	0.003 [− 0.021; 0.027]
Outcome: SBPV, standing	0.009 [− 0.014; 0.032]	0.011 [− 0.013; 0.034]	0.015 [− 0.010; 0.039]	0.014 [− 0.010; 0.038]
Outcome: BRS, seated	−0.018 [− 0.032; − 0.004]	−0.011 [− 0.025; 0.002]	−0.010 [− 0.024; 0.005]	−0.007 [− 0.021; 0.007]
Outcome: BRS, standing	− 0.027 [− 0.042; − 0.012]	−0.019 [− 0.033; − 0.004]	−0.019 [− 0.034; − 0.003]	−0.015 [− 0.030; 0.000]

Bold denotes statistical significance (p ≤ 0.05)
Model I (crude): NPS
Model II (adjusted for lifestyle): Model I + BMI + LTPA + smoking
Model III (adjusted for comorbidities): Model I + HSCL-25 + comorbidity + medication
Model IV (adjusted for lifestyle and comorbidities): Model II + Model III
BMI Body mass index, BRS Baroreflex sensitivity, CI Confidence interval, HR Heart rate, HSCL-25 Hopkins Symptom Checklist-25, LTPA Leisure-time physical activity, NPS Number of pain sites, P P value for β, rMSSD Root mean square of successive differences in R-R intervals, SBPV Systolic blood pressure variability, β Beta coefficient

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