Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis

Table 2 Treatment effect estimates for synovial tissue volume for vitamin D and placebo groups

	Change from baseline. Mean (mm³), 95% CI
	Year 1	Year 2
Vitamin D Therapy	−364.3	155.4
Vitamin D Therapy	(−1439.1 to 710.6)	(−1097.3 to 1408.0)
Placebo	−309.6	61.5
Placebo	(− 1330.6 to 711.4)	(−1085.6 to 1208.6)
Adjusted^a Mean Difference between groups	−54.6	93.9
Adjusted^a Mean Difference between groups	(−1537.8 to 1428.5)	(−1605.0 to 1792.7)

All results presented with 95% confidence intervals (CI)
^a Adjusted mean difference between vitamin D and placebo groups (N = 50) at follow-up generated from random-effects models; adjusted for baseline synovial tissue volume, age and sex

ISSN: 1471-2474