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Table 6 Adiponectin at 18 and 22 years old and BMD at 22 years, females

From: Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

 

BMD - 22 years (mg/cm2)

Total body

β (95% CI)

Lumbar spine

β (95% CI)

Femur neck

β (95% CI)

Crude

Adjusted

Crude

Adjusted

Crude

Adjusted

18 years

      

 Adiponectin (μg/mL - tertiles)

p = 0.031

p = 0.609

p = 0.093

p = 0.246

p = 0.077

p = 0.854

  1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  2

−52.6 (−91.0; − 14.2)

−6.4 (− 49.5; 36.8)

−60.7 (− 114.9; − 6.5)

2.4 (− 66.9; 71.6)

−52.0 (− 113.1; 9.1)

5.4 (− 70.1; 80.9)

  3

− 43.3 (− 82.0; − 4.7)

9.8 (− 33.3; 52.9)

− 47.1 (− 101.7; 7.4)

38.4 (− 30.7; 107.6)

− 55.7 (− 117.2; 5.7)

−6.0 (− 81.6; 69.5)

22 years

      

 Adiponectin (μg/mL - tertiles)

p < 0.001

p = 0.058

p < 0.001

p = 0.033

p < 0.001

p = 0.258

  1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  2

−19.0 (−28.5; − 9.5)

0.78 (− 8.4; 9.9)

−16.8 (− 32.2; − 1.4)

3.5 (− 12.8; 20.0)

−30.7 (− 46.1; − 15.4)

4.9 (− 10.8; 20.6)

  3

−39.6 (− 49.1; − 30.1)

−9.9 (− 18.3; 0.6)

−50.5 (− 65.9; − 35.2)

− 17.8 (− 34.9; − 0.9)

− 56.9 (− 72.2; − 41.5)

− 8.9 (− 25.0; 7.3)

18 and 22 yearsa

      

 Adiponectin in the highest tertile

p = 0.010

p = 0.688

p = 0.153

p = 0.521

p = 0.082

p = 0.806

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only at 18

6.4 (− 40.6; 53.4)

19.9 (− 30.2; 70.0)

0.2 (− 67.1; 67.4)

41.3 (− 39.2; 121.9)

16.0 (− 58.5; 90.4)

16.3 (− 71.6; 104.2)

 Only at 22

−54.0 (− 99.1; − 8.8)

− 15.2 (− 61.2; 30.8)

−57.4 (− 122.0; 7.2)

− 23.2 (− 97.1; 50.7)

−41.2 (− 112.7; 30.4)

−4.7 (− 85.1; 75.8)

 Both 18 and 22 years

− 56.6 (− 98.7; − 14.4)

−2.3 (− 51.0; 46.5)

−53.0 (− 113.4; 7.4)

18.1 (− 60.3; 96.4)

− 77.1 (− 144.0; − 10.2)

− 34.3 (− 119.5; 51.0)

  1. Total females sample 18 years n = 137 / 22 years n = 1688
  2. BMD bone mineral density
  3. Adjusted for birth weight, maternal smoking during pregnancy, gestational age, skin color, schooling (years - 18y), asset index (quintiles - 22y), smoking status (18 and 22y), alcohol use (AUDIT - 18 and 22y), physical activity (minutes per week 18 and 22y), medical diagnosis of asthma, diabetes and hypertension (22y), BMI (continuous - 22y), height (22y), daily calcium intake (18y and 22y), any kind of corticoids use in the last three months (22y), insulin (22y), testosterone (22y), age at menarche, oral contraceptive use in the last year (18 and 22y) and current breastfeeding (22y)
  4. P-values by Wald’s test for linear tendency, except aWald’s test for heterogeneity