Table 3 CRP and Il-6 at 18 and 22 years old and BMD at 22 years, males

CRP (log mg/L - tertiles)

p = 0.009

p = 0.160

p = 0.280

p = 0.082

p = 0.320

p = 0.194

 1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 2

12.9 (0.4; 25.4)

−5.2 (−17.1; 6.7)

8.6 (−9.6; 26.9)

− 10.2 (−29.9; 9.6)

11.4 (− 10.0; 32.7)

−10.3 (−32.3; 11.8)

 3

15.3 (3.5; 27.1)

−8.3 (− 20.0; 3.4)

9.1 (− 8.1; 26.3)

− 17.0 (− 36.4; 2.4)

9.6 (− 10.6; 29.8)

−14.0 (− 35.7; 7.6)

IL-6 (log pg/mL - tertiles)

p = 0.625

p = 0.90

p = 0.596

p = 0.317

p = 0.882

p = 0.504

 1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 2

−8.9 (−21.3; 3.5)

−17.2 (− 29,0; − 5.4)

− 7.0 (− 25.0; 11.0)

−16.1 (− 35.7; 3.4)

−4.0 (− 25.0; 17.0)

−8.7 (− 30.5; 13.1)

 3

−3.0 (− 15.3; 9.4)

− 10.3 (− 22.1; 1.6)

−4.8 (− 22.7; 13.2)

−10.0 (− 29.6; 9.7)

1.7 (− 19.3; 22.7)

−7.4 (− 29.4; 14.5)

CRP and IL-6 in the highest tertile

p = 0.264

p = 0.364

p = 0.830

p = 0.308

p = 0.672

p = 0.415

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only CRP or IL-6

11.4 (− 0.4; 23.1)

4.2 (−7.2; 15.5)

5.8 (− 11.3; 23.0)

−6.8 (− 25.6; 12.0)

11.3 (− 8.8; 31.3)

− 3.2 (− 24.2; 17.8)

 Both CRP and IL-6

4.3 (−9.5; 18.2)

−8.6 (− 21.8; 4.5)

0.1 (− 20.0; 20.2)

− 10.3 (− 32.1; 11.4)

1.10 (− 22.5; 24.7)

− 10.4 (− 34.8; 14.0)

CRP (log mg/L - tertiles)

p = 0.001

p = 0.939

p = 0.032

p = 0.413

p = 0.008

p = 0.834

 1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 2

21.4 (9.1; 33.7

−0.3 (−12.2; 11.6)

16.0 (−1.9; 33.8)

−3.0 (− 22.7; 16.7)

18.6 (− 2.2; 39.5)

−5.6 (− 27.6; 16.5)

 3

20.5 (8.6; 32.5)

0.5 (− 11.6; 12.6)

18.7 (1.3; 36.2)

8.5 (− 11.3; 28.6)

27.0 (6.7; 47.3)

3.8 (− 18.5; 26.1)

IL-6 (log pg/mL - tertiles)

p = 0.018

p = 0.250

p = 0.275

p = 0.193

p = 0.072

p = 0.216

 1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 2

7.9 (−4.4; 20.1)

4.5 (−7.4; 16.3)

12.8 (−5.0; 30.7)

11.5 (−8.1; 31.1)

9.3 (−11.5; 30.2)

5.7 (−16.1; 27.6)

 3

15.0 (2.6; 27.5)

7.2 (−5.1; 19.6)

9.8 (−8.3; 28.0)

13.4 (−7.0; 33.8)

19.4 (−1.8; 40.5)

14.4 (−8.4; 37.2)

CRP and IL-6 in the highest tertile

p = 0.014

p = 0.527

p = 0.211

p = 0.225

p = 0.025

p = 0.258

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only CRP or IL-6

5.1 (−6.8; 17.1)

−1.4 (−13.0; 10.1)

4.9 (−12.6; 22.4)

4.3 (− 14.9; 23.4)

14.5 (−5.9; 34.8)

5.1 (− 16.3; 26.4)

 Both CRP and IL-6

17.6 (4.0; 31.2)

5.6 (−8.1; 19.3)

12.58 (−7.3; 32.4)

14.4 (− 8.2; 37.1)

24.7 (1.6; 47.8)

14.8 (−10.5; 40.1)

CRP in the highest tertile

p = 0.065

p = 0.469

p = 0.279

p = 0.155

p = 0.071

p = 0.378

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only at 18

12.2 (−2.1; 26.5)

−1.8 (15.6; 12.1)

9.1 (−11.7; 30.0)

−7.6 (−30.5; 15.3)

11.1 (− 13.3; 35.5)

− 2.1 (− 27.8; 23.6)

 Only at 22

15.2 (1.3; 29.1)

6.2 (−7.4; 19.8)

19.4 (−0.9; 39.7)

20.5 (−2.0; 43.0)

31.8 (8.1; 55.5)

17.9 (−7.2; 43.0)

 Both 18 and 22 years

13.9 (− 1.1; 29.0)

−7.5 (−22.3; 7.2)

10.1 (−11.9; 32.1)

−6.9 (− 31.4;17.5)

11.6 (−14.0; 37.1)

−8.2 (− 35.5; 19.0)

IL-6 in the highest tertile

p = 0.258

p = 0.708

p = 0.935

p = 0.851

p = 0.365

p = 0.681

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only at 18

−.19 (−13.8; 13.4)

0.5 (−12.5; 13.4)

−4.7 (−24.6; 15.3)

−3.3 (−24.7; 18.1)

− 4.49 (−27.7; 18.8)

−4.6 (−28.6; 19.3)

 Only at 22

11.4 (−2.6; 25.4)

7.9 (−5.6; 21.4)

1.3 (−19.0; 21.7)

7.5 (− 14.8; 29.9)

8.42 (−15.3; 32.1)

12.0 (− 13.0; 36.9)

 Both 18 and 22 years

10.7 (− 4.8; 26.3)

1.1 (− 14.0; 16.2)

3.5 (− 19.2; 26.2)

5.0 (−20.1; 30.0)

20.4 (− 6.0; 46.8)

7.6 (−20.3; 35.5)

Both CRP and IL-6 in the highest tertile

p = 0.117

p = 0.268

p = 0.692

p = 0.505

p = 0.336

p = 0.561

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only at 18

−0.9 (− 16.8; 15.0)

−11.3 (− 26.4; 3.9)

−2.95 (− 26.2; 20.3)

−9.8 (−35.0; 15.3)

−5.7 (− 33.0; 21.5)

− 12.4 (− 40.7; 15.8)

 Only at 22

17.7 (2.2; 33.2)

8.5 (−6.9; 24.0)

12.8 (− 9.8; 35.5)

15.7 (− 10.0; 41.3)

21.8 (−4.6; 48.2)

14.7 (− 14.0; 43.3)

 18 and 22 years

11.2 (−10.5; 32.9)

−3.5 (−23.9; 16.9)

4.7 (− 26.7; 36.2)

−1.8 (−31.7; 35.4)

12.8 (− 23.9; 49.5)

3.4 (−34.1; 40.9)