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Table 2 Unadjusted and Adjusted Associations of sxKOA and HAQ Scores with Incident CVD

From: Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease

Variable

Unadjusted

Model 1a

Model 2a

OR (95% CI)

OR (95% CI)

OR (95% CI)

sxKOA vs. no sxKOA at baseline

1.50 (1.08, 2.08)

1.14 (0.80, 1.61)

1.10 (0.76, 1.61)

Baseline 0 < HAQ < 1 vs. HAQ = 0

1.29 (0.97, 1.72)

1.17 (0.87, 1.57)

1.08 (0.79, 1.47)

Baseline 1 ≤ HAQ vs. HAQ = 0

1.94 (1.32, 2.85)

1.91 (1.27, 2.86)

1.82 (1.18, 2.79)

Worsened HAQ vs. unchanged or improved

2.51 (1.93, 3.27)

2.49 (1.90, 3.25)

2.35 (1.79, 3.10)

Age: 1 year increase

  

1.02 (1.00, 1.03)

Gender: Female vs. Male

  

1.28 (0.91, 1.80)

Race: Black vs. White

  

1.13 (0.83, 1.54)

Education: <HS vs. HS or greater

  

0.89 (0.65, 1.24)

Cohort: Enrichment vs. Original

  

0.96 (0.69, 1.33)

BMI: 1 kg/m2 increase

  

0.98 (0.95, 1.00)

WHR: 0.1 unit increase

  

1.15 (0.98, 1.36)

Diabetes vs. not

  

1.84 (1.21, 2.80)

Hypertension vs. not

  

1.10 (0.81, 1.48)

High cholesterol vs. not

  

1.03 (0.74, 1.44)

NSAIDs vs. not

  

1.27 (0.94, 1.71)

  1. CI confidence interval, sxKOA symptomatic knee osteoarthritis, HAQ health assessment questionnaire, HS high school, BMI body mass index, WHR waist-to-hip ratio, NSAIDs non-steroidal anti-inflammatory drugs
  2. aModels 1 and 2 are adjusted for all variables with data listed in the column
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BMC Musculoskeletal Disorders

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