Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis

Huang, Donghua; Deng, Xiangyu; Ma, Kaige; Wu, Fashuai; Shi, Deyao; Liang, Hang; Chen, Sheng; Shao, Zengwu

doi:10.1186/s12891-018-2297-y

BMC Musculoskeletal Disorders

Table 1 Main Characteristics of Studies Included in This Meta-analysis for COL9A3 trp3 Polymorphisms

From: Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis

Study ID	year	Enrolled Country	Ethnicity	Age	Gender	Diagnosis by	Genotyping Method	Control Source	Matching	Cases	Controls	Relation with IDD
Bagheri et al. [18]	2016	Iran	Iranian	20~ 66	both	MRI	PCR-seq	individuals with acute trauma and patients without IDD	gender	108	57	only present in male subgroup
Solovieva et al. [14]	2006	Finland	N/D	40~ 45	men	MRI	PCR-seq	Patients without IDD	HWE, age	77	55	Absent
Kales et al. [27]	2004	Greece	Southern European	< 60	both	surgery, MRI or CT	PCR-seq	patients without IDD and visitors to nonsurgical, nonorthopedic units	BMI	105	102	Absent
Paassita et al. [17]	2001	Finland	Finnish	< 78	N/D	both clinic and MRI or CT	PCR-seq CSGE	healthy individuals, osteoarthritis, rheumatoid arthritis, chondrodysplasias	N/D	171	321	Present
Kelempisioti et al. [30]	2011	Finland	N/D	young adult, mean age 21	both	MRI	PCR-seq	Patients without IDD	gender, HWE	292	246	Absent
Matsui et al. [28]	2004	USA	most of them are Caucasian	16~ 87	both	N/D	PCR-seq	Individuals with a vertebral fracture treated by fusion	N/D^a	97	10	Absent^b
Eskola et al. [21]	2010	Finland	Caucasian	12 ~ 14	both	MRI	PCR-seq	children without IDD	age, weight, BMI, HWE	66	154	Absent
Rathod et al. [22]	2012	India	Indian	15~ 60	both	both clinic and MRI	PCR-seq and TaqMan assay	Patients without IDD	age	100	100	Absent
Zhu et al. [29]	2011	USA	most of them are Caucasian	16~ 78	both	N/D	N/D	Individuals with a vertebral fracture treated by fusion	age	26	6	N/D
jim et al. [23]	2005	China	Chinese	18~ 55	both	MRI	PCR-seq CSGE	Patients without IDD	age, gender	514	290	Absent
Toktas et al. [11]	2015	Turkey	N/D	35~ 45	male	MRI	PCR-seq	healthy individuals	age, gender	75	25	Absent^c

Abbreviations: PCR-seq restriction analysis polymerase chain reaction sequencing, N/D not described, CSGE conformation sensitive gel electrophoresis, MRI magnetic resonance imaging, CT Computed Tomography, IDD intervertebral disk degeneration, HWE Hardy–Weinberg equilibrium, BMI body mass index. ^aThis study matched age, gender, race between trp3 positive and trp3 negative groups, but not between control and case groups. ^b, although absent relation with IDD, case group was positively associated with the diagnosis of spinal stenosis with spondylolisthesis. ^c, although absent relation with IDD, control group has significantly higher scores in Pfirrmann classification than case group

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ISSN: 1471-2474

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