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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone

Fig. 1

Study design. The right knee joint had an intra-articular injection of MIA at day 0. The left knee had PBS as a control. Histological and immunohistochemical evaluations (hematoxylin and eosin/safranin O staining and calcitonin gene-related peptide staining) were performed at 5, 14, and 28 days post-injection. The pain avoidance behavior tests (incapacitance and von Frey) were performed as indicated

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